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Study Information
Study Attribute Value
CEBS Accession Number: 002-01989-0001-0000-0
Chemical Name: Diazinon
CASRN: 333-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 140422_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 428 0.411 8.56 25.5 0.000
Test Chemical Diazinon 
1.1       
 50 1029 415 0.403 8.30 25.5 -1.907 
3.5       
 50 1030 463 0.450 9.26 32.0 9.333 
10.6       
 50 1038 480 0.462 9.60 32.0 12.474 
35.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1032 509 0.493 10.18 25.5 19.962
Mitomycin-C 
 0.01      
 5 105 223 2.124 44.60 25.5 416.562
Trend: 2.191        
Probability: 0.014        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/06/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 391 0.374 7.82 25.5 0.000
Test Chemical Diazinon 
1.1       
 50 1033 406 0.393 8.12 25.5 5.043 
3.5       
 50 1043 367 0.352 7.34 25.5 -5.958 
10.6       
 50 1033 381 0.369 7.62 25.5 -1.426 
35.2       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1037 626 0.604 12.52 25.5 61.337
Cyclophosphamide 
2         
 5 105 180 1.714 36.00 25.5 358.166
Trend: -0.681        
Probability: 0.752