COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01989-0002-0000-1
Chemical Name: Diazinon
CASRN: 333-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 140422_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Test Failure 

Trial #:1   Activation: No Activation    Date: 12/19/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 6.0 3 0.030 3.0 4 0.040 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0
Test Chemical: Diazinon 
30.2       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
40.2       
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
60         
 58 2 0.034 2.0 0 0.000 0.0 2 0.034 2.0 0 0.000 0.0 
80         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 13 0.130 11.0 5 0.050 5.0 5 0.050 5.0 3 0.030 2.0
Mitomycin-C 
 0.5       
 25 9 0.360 28.0 2 0.080 8.0 7 0.280 20.0 0 0.000 0.0
Trend: -1.249 -0.493 -0.602  
Probability: 0.894 0.689 0.727  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/21/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: Diazinon 
5         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
7.5       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
10         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
30.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 12 0.120 11.0 4 0.040 4.0 7 0.070 7.0 1 0.010 1.0
Cyclophosphamide 
37.5       
 25 9 0.360 24.0 2 0.080 8.0 6 0.240 16.0 1 0.040 1.0
Trend: -0.672 -0.256 -0.622  
Probability: 0.749 0.601 0.733  


Trial #:2   Activation: No Activation    Date: 11/21/1984    Harvest Time: 10.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: Diazinon 
50.6       
 100 7 0.070 3.0 0 0.000 0.0 7 0.070 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 25 17 0.680 24.0 4 0.160 16.0 3 0.120 8.0 10 0.400 4.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000