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Study Information
Study Attribute Value
CEBS Accession Number: 002-01989-0002-0000-1
Chemical Name: Diazinon
CASRN: 333-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 140422_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Test Failure 

Trial #:1   Activation: No Activation    Date: 12/19/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 7 0.070 6.0 3 0.030 3.0 4 0.040 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 6.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0
Test Chemical: Diazinon 
30.2       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
40.2       
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0 
60         
 58 2 0.034 2.0 0 0.000 0.0 2 0.034 2.0 0 0.000 0.0 
80         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 13 0.130 11.0 5 0.050 5.0 5 0.050 5.0 3 0.030 2.0
Mitomycin-C 
 0.5       
 25 9 0.360 28.0 2 0.080 8.0 7 0.280 20.0 0 0.000 0.0
Trend: -1.249 -0.493 -0.602  
Probability: 0.894 0.689 0.727  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/21/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 0 0.000 0.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: Diazinon 
5         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
7.5       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
10         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
30.4       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 12 0.120 11.0 4 0.040 4.0 7 0.070 7.0 1 0.010 1.0
Cyclophosphamide 
37.5       
 25 9 0.360 24.0 2 0.080 8.0 6 0.240 16.0 1 0.040 1.0
Trend: -0.672 -0.256 -0.622  
Probability: 0.749 0.601 0.733  


Trial #:2   Activation: No Activation    Date: 11/21/1984    Harvest Time: 10.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 3.0 1 0.010 1.0 2 0.020 2.0 1 0.010 1.0
Test Chemical: Diazinon 
50.6       
 100 7 0.070 3.0 0 0.000 0.0 7 0.070 3.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 25 17 0.680 24.0 4 0.160 16.0 3 0.120 8.0 10 0.400 4.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000