Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01989-0008-0000-7
Chemical Name: Diazinon
CASRN: 333-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 180250
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 73 95 174 79 63
    91 115 147 54
    79 90 135 57
    74 99 134 60
Test Chemical Diazinon 
6.25      
 72 99 126 58 66
    53 96 115 73
  
12.5       
 63 78 131 69 62
    55 80 91 55
  
25         
 42 58 128 101 92
    62 71 154 83
  
50         
 79 65 194 82 81
    91 61 222 81
  
100         
 39 9 202 173 209*
    37 6 273 245
  
200         
   
Positive Control Methyl Methane Sulfonate 
15         
 34 28 427 425 378*
    39 25 390 331

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 66 97 203 102 77
    90 100 161 59
    75 98 152 68
    79 105 188 79
Test Chemical Diazinon 
20         
 82 98 236 96 95
    80 102 225 93
  
40         
 83 80 231 93 83
    69 77 148 72
  
60         
 69 62 396 193 180*
    79 72 397 168
  
80         
 67 19 2454 1224 1313*
    60 19 2532 1403
  
100         
   
Positive Control Methyl Methane Sulfonate 
15         
 32 27 95 99 115
    30 36 116 130

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination