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Study Information
Study Attribute Value
CEBS Accession Number: 002-01993-0001-0000-5
Chemical Name: Dibenzofuran
CASRN: 132-64-9
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 578267_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 06/02/1981    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 390 0.379 7.80 25.0 0.000
Test Chemical Dibenzofuran 
3.3       
 50 1046 365 0.349 7.30 25.0 -7.931 
11         
 50 1037 433 0.418 8.66 25.0 10.169 
33         
 50 1045 414 0.396 8.28 28.0 4.529
Positive Control Triethylenemelamine 
 0.015     
 50 1032 1792 1.736 35.84 25.0 358.151
Trend: 1.425        
Probability: 0.077        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/08/1981    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 469 0.449 9.38 26.0 0.000
Test Chemical Dibenzofuran 
3.3       
 50 1014 507 0.500 10.14 26.0 11.301 
10         
 50 1027 586 0.571 11.72 26.0 27.015 
33         
 50 1030 527 0.512 10.54 26.0 13.894
Positive Control Cyclophosphamide 
1.5       
 50 1028 1475 1.435 29.50 26.0 219.394
Trend: 2.574        
Probability: 0.005