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Study Information
Study Attribute Value
CEBS Accession Number: 002-02000-0001-0000-5
Chemical Name: Dibromomannitol
CASRN: 488-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 953018_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/19/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 535 0.517 10.70 26.0 0.000
Test Chemical Dibromomannitol 
1.7       
 50 1034 775 0.750 15.50 26.0 45.000 
5         
 10 208 479 2.303 47.90 26.0 345.511 
16.7       
 5 104 874 8.404 174.80 32.8 1525.791 
50         
 0 0 0 0.000 0.00 32.8 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1032 798 0.773 15.96 26.0 49.592
Mitomycin-C 
 0.01      
 5 104 212 2.038 42.40 26.0 294.357
Trend: 58.675        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/02/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 526 0.507 10.52 26.0 0.000
Test Chemical Dibromomannitol 
5         
 10 204 868 4.255 86.80 26.0 738.847 
10         
 5 105 622 5.924 124.40 26.0 1067.869 
15         
 5 104 816 7.846 163.20 33.5 1446.856 
20         
 0 0 0 0.000 0.00 33.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1032 699 0.677 13.98 26.0 33.534
Mitomycin-C 
 0.01      
 5 104 235 2.260 47.00 26.0 345.479
Trend: 64.368        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/19/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 442 0.431 8.84 26.0 0.000
Test Chemical Dibromomannitol 
50         
 50 1039 886 0.853 17.72 26.0 97.751 
167         
 15 315 604 1.917 40.27 26.0 344.660 
500         
 10 203 816 4.020 81.60 32.8 832.171 
1700         
 5 104 656 6.308 131.20 32.8 1362.757 
5000         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 756 0.730 15.12 26.0 69.388
Cyclophosphamide 
2         
 5 106 135 1.274 27.00 26.0 195.345
Trend: 59.981        
Probability: 0.000