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Study Information
Study Attribute Value
CEBS Accession Number: 002-02000-0002-0000-6
Chemical Name: Dibromomannitol
CASRN: 488-41-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 953018_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 09/11/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Dibromomannitol 
200         
 10 30 3.000 100.0 12 1.200 60.0 16 1.600 80.0 2 0.200 20.0 
300         
 10 53 5.300 80.0 3 0.300 20.0 8 0.800 30.0 42 4.200 50.0 
400         
 10 91 9.100 100.0 11 1.100 30.0 10 1.000 50.0 70 7.000 70.0
Positive Control: Mitomycin-C 
 0.04      
 100 42 0.420 31.0 19 0.190 18.0 23 0.230 19.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 21 0.840 52.0 7 0.280 24.0 14 0.560 40.0 0 0.000 0.0
Trend: 9.430 4.343 5.593  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 08/22/1984    Harvest Time: 10.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 1.0 0 0.000 0.0 3 0.030 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dibromomannitol 
1000         
 100 9 0.090 7.0 5 0.050 4.0 4 0.040 4.0 0 0.000 0.0 
2500         
 100 19 0.190 13.0 9 0.090 8.0 10 0.100 7.0 0 0.000 0.0 
5000         
 100 17 0.170 12.0 8 0.080 7.0 9 0.090 6.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 10 0.100 9.0 2 0.020 2.0 8 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 7 0.280 16.0 3 0.120 12.0 4 0.160 12.0 0 0.000 0.0
Trend: 3.523 2.682 2.376  
Probability: 0.000 0.004 0.009  


Trial #:2   Activation: No Activation    Date: 08/15/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 6 0.060 4.0 0 0.000 0.0 6 0.060 4.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Dibromomannitol 
150         
 25 65 2.600 88.0 38 1.520 76.0 27 1.080 64.0 0 0.000 0.0 
175         
 25 60 2.400 80.0 32 1.280 64.0 17 0.680 28.0 11 0.440 2.0 
200         
 25 49 1.960 80.0 28 1.120 68.0 21 0.840 56.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.04      
 100 25 0.250 18.0 11 0.110 10.0 14 0.140 11.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 9 0.360 36.0 5 0.200 20.0 4 0.160 16.0 0 0.000 0.0
Trend: 9.239 8.455 5.994  
Probability: 0.000 0.000 0.000