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Study Information
Study Attribute Value
CEBS Accession Number: 002-02003-0001-0000-8
Chemical Name: Dibutyltin diacetate
CASRN: 1067-33-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 092968_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 05/21/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Ethanol 
0         
 50 1010 497 0.492 9.94 34.0 0.000
Negative (Not Specified) 
0         
 50 1030 414 0.402 8.28 26.0 -18.318
Test Chemical Dibutyltin diacetate 
 0.1       
 50 1013 477 0.471 9.54 34.0 -4.308 
 0.15      
 50 1022 511 0.500 10.22 34.0 1.610 
 0.2       
 25 518 289 0.558 11.56 34.0 13.379 
 0.25      
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1042 654 0.628 13.08 26.0 27.548
Mitomycin-C 
 0.01      
 5 103 164 1.592 32.80 26.0 223.573
Trend: 1.617        
Probability: 0.053        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/28/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1027 444 0.432 8.88 26.0 -33.157
Ethanol 
0         
 50 1039 672 0.647 13.44 26.0 0.000
Test Chemical Dibutyltin diacetate 
 0.433     
 50 1035 630 0.609 12.60 26.0 -5.888 
1.3       
 50 1024 797 0.778 15.94 34.0 20.339 
4.33      
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1046 578 0.553 11.56 26.0 -14.564
Cyclophosphamide 
2         
 5 105 140 1.333 28.00 26.0 106.151
Trend: 3.571        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/21/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 519 0.497 10.38 26.0 -4.640
Ethanol 
0         
 50 1032 538 0.521 10.76 34.0 0.000
Test Chemical Dibutyltin diacetate 
 0.5       
 50 1034 571 0.552 11.42 34.0 5.929 
 0.72      
 25 511 346 0.677 13.84 34.0 29.883 
1.04      
 0 0 0 0.000 0.00 34.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1033 671 0.650 13.42 34.0 24.600
Cyclophosphamide 
2         
 5 104 131 1.260 26.20 26.0 141.621
Trend: 3.584        
Probability: 0.000