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Study Information
Study Attribute Value
CEBS Accession Number: 002-02008-0001-0000-3
Chemical Name: Dichloroacetonitrile
CASRN: 3018-12-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 699204_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/31/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 541 0.521 10.82 26.0 0.000
Test Chemical Dichloroacetonitrile 
 0.47      
 50 1028 559 0.544 11.18 26.0 4.433 
1.4       
 50 1040 566 0.544 11.32 26.0 4.520 
4.7       
 50 1037 711 0.686 14.22 26.0 31.677 
14         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1043 713 0.684 14.26 26.0 31.288
Mitomycin-C 
 0.01      
 5 102 248 2.431 49.60 26.0 366.949
Trend: 4.767        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/14/1984    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 426 0.410 8.52 26.0 0.000
Test Chemical Dichloroacetonitrile 
1.5       
 50 1024 472 0.461 9.44 26.0 12.529 
2.5       
 50 1039 518 0.499 10.36 26.0 21.713 
4.9       
 50 1041 478 0.459 9.56 31.5 12.099 
7.5       
 0 0 0 0.000 0.00 31.5 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1036 577 0.557 11.54 26.0 35.969
Mitomycin-C 
 0.01      
 5 104 202 1.942 40.40 26.0 374.178
Trend: 1.845        
Probability: 0.032        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/31/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 503 0.484 10.06 26.0 0.000
Test Chemical Dichloroacetonitrile 
4.7       
 50 1035 532 0.514 10.64 26.0 6.276 
14         
 50 1042 568 0.545 11.36 26.0 12.706 
47         
 50 1037 854 0.824 17.08 26.0 70.272 
140         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1045 696 0.666 13.92 26.0 37.708
Cyclophosphamide 
2         
 5 105 158 1.505 31.60 26.0 211.124
Trend: 9.948        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/10/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1019 469 0.460 9.38 26.0 0.000
Test Chemical Dichloroacetonitrile 
25         
 50 1011 661 0.654 13.22 34.0 42.053 
50         
 50 1028 672 0.654 13.44 34.0 42.029 
75         
 50 1019 1050 1.030 21.00 34.0 123.881 
99         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1005 736 0.732 14.72 26.0 59.116
Cyclophosphamide 
2         
 5 106 194 1.830 38.80 26.0 297.647
Trend: 13.966        
Probability: 0.000