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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0001-0000-9
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 584062_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 12/05/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 456 0.438 9.12 26.0 0.000
Negative (Not Specified) 
0         
 50 1024 395 0.386 7.90 26.0 -11.855
Test Chemical Dichlorvos 
1.6       
 50 1050 357 0.340 7.14 26.0 -22.307 
5         
 50 1028 449 0.437 8.98 26.0 -0.194 
16         
 50 1040 587 0.564 11.74 26.0 28.976 
50         
 0 0 0 0.000 0.00 26.0 N/A 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.003     
 50 1036 1537 1.484 30.74 26.0 239.013
Trend: 5.179        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/16/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 435 0.422 8.70 26.0 0.000
Test Chemical Dichlorvos 
1         
 50 1027 422 0.411 8.44 26.0 -2.611 
5         
 50 1025 497 0.485 9.94 26.0 14.922 
10         
 50 1034 656 0.634 13.12 26.0 50.367
Positive Control Mitomycin-C 
 0.005     
 50 1039 1385 1.333 27.70 26.0 215.939
Trend: 6.944        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/05/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 422 0.404 8.44 26.0 -8.673
Dimethyl Sulfoxide 
0         
 50 1029 455 0.442 9.10 26.0 0.000
Test Chemical Dichlorvos 
50         
 50 1033 488 0.472 9.76 26.0 6.837 
160         
 50 1043 601 0.576 12.02 26.0 30.315 
500         
 45 921 1187 1.289 26.38 26.0 191.471 
1600         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 50 1035 3489 3.371 69.78 26.0 662.368
Trend: 21.818        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/16/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 463 0.446 9.26 26.0 3.317
Dimethyl Sulfoxide 
0         
 50 1040 449 0.432 8.98 26.0 0.000
Test Chemical Dichlorvos 
100         
 50 1038 527 0.508 10.54 26.0 17.598 
200         
 50 1039 742 0.714 14.84 26.0 65.415 
300         
 50 1033 834 0.807 16.68 26.0 87.005 
400         
 50 1028 949 0.923 18.98 26.0 113.826 
500         
 50 1034 1197 1.158 23.94 26.0 168.139
Positive Control Cyclophosphamide 
1.5       
 50 1043 1441 1.382 28.82 26.0 220.012
Trend: 21.497        
Probability: 0.000