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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0002-0000-0
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 584062_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive* 
Induced Rat Liver S9  1_S9  Weakly Positive 
No Activation  2  Weakly Positive* 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 12/14/1983    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Dichlorvos 
16         
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
50         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
160         
 100 22 0.220 21.0 5 0.050 5.0 17 0.170 16.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 58 0.580 40.0 29 0.290 24.0 29 0.290 23.0 0 0.000 0.0
Trend: 4.792 1.438 4.718  
Probability: 0.000 0.075 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/14/1983    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Dichlorvos 
50         
 100 7 0.070 5.0 1 0.010 1.0 5 0.050 3.0 1 0.010 1.0 
160         
 100 8 0.080 8.0 3 0.030 3.0 4 0.040 4.0 1 0.010 1.0 
500         
 100 19 0.190 19.0 11 0.110 11.0 8 0.080 8.0 0 0.000 0.0 
1600         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 46 0.460 37.0 25 0.250 21.0 21 0.210 19.0 0 0.000 0.0
Trend: 0.983 1.038 0.534  
Probability: 0.163 0.150 0.297  


Trial #:2   Activation: No Activation    Date: 12/20/1983    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Dichlorvos 
50         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
100         
 100 5 0.050 5.0 0 0.000 0.0 5 0.050 5.0 0 0.000 0.0 
160         
 100 16 0.160 16.0 7 0.070 7.0 9 0.090 9.0 0 0.000 0.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 57 0.570 42.0 33 0.330 29.0 24 0.240 17.0 0 0.000 0.0
Trend: 4.027 2.999 2.763  
Probability: 0.000 0.001 0.003  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 12/20/1983    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Dichlorvos 
500         
 100 8 0.080 7.0 1 0.010 1.0 7 0.070 6.0 0 0.000 0.0 
750         
 100 33 0.330 23.0 9 0.090 8.0 24 0.240 18.0 0 0.000 0.0 
1000         
 100 70 0.700 46.0 17 0.170 17.0 49 0.490 39.0 4 0.040 4.0 
1500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 100 59 0.590 40.0 39 0.390 27.0 20 0.200 20.0 0 0.000 0.0
Trend: 8.022 4.823 7.324  
Probability: 0.000 0.000 0.000