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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0013-0000-2
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 282595
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 77 126 132 57 46
    73# 79 111 51
    62# 94 58 31
Test Chemical Dichlorvos 
12.5       
 49# 88 77 52 48
    53# 109 70 44
  
25         
 75 104 96 43 47
    59 98 69 39
    43 92 76 60
  
100         
 39# 7 492 422 351*
    40# 18 485 402
    71# 32 487 228
  
200         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 57 61 537 313 313*

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 130r 113 115 30 44
    114 116 102 30
    111# 91 153 46
    95 93 161 56
Test Chemical Dichlorvos 
6.25      
 94 68 142 51 45
    100 84 116 39
    74 86 101 45
  
12.5       
 80 58 131 54 74*
    98 51 215 73
    105 43 295 93
  
25         
 71 25 492 230 305*
    65 8 754 387
    73# 9 656 299
  
50         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 73 64 505 231 237*
    63 46 433 228
    79# 69 603 254

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination