Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02013-0013-0000-2
Chemical Name:	Dichlorvos
CASRN:	62-73-7
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	282595
Study Result:	Positive

View Study Details | View Protocol | Download To Excel

Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	77	126	132	57	46
			73#	79	111	51
			62#	94	58	31
Test Chemical	Dichlorvos	12.5	49#	88	77	52	48
			53#	109	70	44	48
		25	75	104	96	43	47
			59	98	69	39
			43	92	76	60
		100	39#	7	492	422	351*
			40#	18	485	402
			71#	32	487	228
		200


Positive Control	Methyl Methane Sulfonate	5	57	61	537	313	313*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	130r	113	115	30	44
			114	116	102	30
			111#	91	153	46
			95	93	161	56
Test Chemical	Dichlorvos	6.25	94	68	142	51	45
			100	84	116	39
			74	86	101	45
		12.5	80	58	131	54	74*
			98	51	215	73
			105	43	295	93
		25	71	25	492	230	305*
			65	8	754	387
			73#	9	656	299
		50


Positive Control	Methyl Methane Sulfonate	5	73	64	505	231	237*
			63	46	433	228
			79#	69	603	254

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination