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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0014-0000-3
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 755734_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/14/83 17 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  17 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.31 ± 0.530
Test Chemical Dichlorvos 
6.25      
 4 4.39 ± 0.774
  
12.5       
 4 5.21 ± 0.678
  
25         
 4 3.85 ± 0.339


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/29/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.54 ± 0.478
Test Chemical Dichlorvos 
3.25      
 4 5.54 ± 1.424
  
6.5       
 4 5.17 ± 0.474
  
13         
 4 4.70 ± 0.256
Positive Control Mitomycin-C 
 0.5       
 4 10.32 ± 0.726


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed