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Study Information
Study Attribute Value
CEBS Accession Number: 002-02013-0015-0000-4
Chemical Name: Dichlorvos
CASRN: 62-73-7
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 755734_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/15/83 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.6161
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical Dichlorvos 
6.25      
 8 0.75 ± 0.53 0.9749
  
12.5       
 8 1.75 ± 0.45 0.7690
  
25         
 8 1.75 ± 0.70 0.7690
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.63 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/09/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1112
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.00 ± 1.51 0.0000
Test Chemical Dichlorvos 
3.2       
 8 0.75 ± 0.53 0.5000
  
6.5       
 8 2.00 ± 0.76 0.0645
  
13         
 8 1.50 ± 0.50 0.1573
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed