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Study Information
Study Attribute Value
CEBS Accession Number: 002-02014-0001-0000-0
Chemical Name: Dicofol
CASRN: 115-32-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 379968_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 01/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 430 0.411 8.60 26.0 0.000
Test Chemical Dicofol 
5         
 50 1046 453 0.433 9.06 26.0 5.349 
16         
 50 1047 470 0.449 9.40 26.0 9.198 
50         
 50 1049 492 0.469 9.84 26.0 14.091
Positive Control Mitomycin-C 
 0.005     
 25 522 599 1.148 23.96 26.0 179.138
Trend: 2.067        
Probability: 0.019        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 475 0.453 9.50 26.0 0.000
Test Chemical Dicofol 
50         
 50 1044 416 0.398 8.32 26.0 -12.086 
160         
 50 1047 506 0.483 10.12 26.0 6.628 
500         
 50 1045 496 0.475 9.92 26.0 4.721
Positive Control Cyclophosphamide 
1         
 50 1046 888 0.849 17.76 26.0 87.305
Trend: 1.605        
Probability: 0.054