Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02020-0001-0000-7 |
Chemical Name: | Dicyclopentadiene |
CASRN: | 77-73-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | A02442_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 5 | 0.025 | 1.0 | 2 | 0.010 | 1.0 | 3 | 0.015 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Dicyclopentadiene | 20 | 200 | 6 | 0.030 | 3.0 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
30 | 200 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
44 | 200 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 | ||
67 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
100 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.4 | 25 | 9 | 0.360 | 32.0 | 5 | 0.200 | 20.0 | 4 | 0.160 | 16.0 | 0 | 0.000 | 0.0 |
Trend: | -0.682 | -1.196 | -0.735 | ||||||||||||
Probability: | 0.752 | 0.884 | 0.769 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 200 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 200 | 3 | 0.015 | 1.5 | 1 | 0.005 | 0.5 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | |
Test Chemical: | Dicyclopentadiene | 30 | 200 | 3 | 0.015 | 1.0 | 1 | 0.005 | 0.5 | 2 | 0.010 | 0.5 | 0 | 0.000 | 0.0 |
44 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
67 | 200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 0.5 | 1 | 0.005 | 0.5 | 0 | 0.000 | 0.0 | ||
100 | 0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 20 | 25 | 10 | 0.400 | 32.0 | 8 | 0.320 | 32.0 | 2 | 0.080 | 4.0 | 0 | 0.000 | 0.0 |
Trend: | -0.448 | 0.000 | -0.600 | ||||||||||||
Probability: | 0.673 | 0.500 | 0.726 |