Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02021-0010-0000-8
Chemical Name: Dieldrin
CASRN: 60-57-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 145014
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 84 103 81 32 29
    90 101 96 36
    89 95 42 16
    97 101 91 31
Test Chemical Dieldrin 
5         
 76 61 89 39 39
    65 60 75 38
  
10         
 75 61 46 20 27
    77 59 76 33
  
20         
 58 34 51 29 32
    65 40 68 35
  
30         
 80 34 72 30 32
    82 37 82 33
  
40         
 66 11 65 33 30
    74 13 61 28
Positive Control Methyl Methane Sulfonate 
20         
 20 9 159 263 256*
    24 10 178 249
Methyl Methane Sulfonate 
250         
 53 42 540 341 305*
    72 51 579 270

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 77 114 66 29 29
    81 104 61 25
    74 89 85 38
    72 93 56 26
Test Chemical Dieldrin 
10         
 58 59 66 38 48*
    76 66 132 58
  
20         
 59 35 106 60 75*
    55 44 148 89
  
30         
 58 25 196 113 147*
    34 17 181 180
  
40         
 37 5 576 524 420*
    49 10 463 317
  
50         
   
Positive Control Methyl Methane Sulfonate 
15         
 23 19 175 250 218*
    23 19 128 186

Nonactivation Trial: 3 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 82 93 119 49 46
    82 111 93 38
    85 106 102 40
    71 90 124 58
Test Chemical Dieldrin 
5         
 77 76 124 54 49
    74 73 96 44
  
10         
 82 73 120 49 42
    72 70 77 35
  
20         
 74 43 124 56 58
    63 46 114 60
  
30         
 57 19 175 103 106*
    48 17 156 109
  
40         
 39 4 316 274 268*
    36 5 284 263
  
50         
   
Positive Control Methyl Methane Sulfonate 
15         
 48 30 335 233 234*
    48 31 339 236

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination