Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02021-0010-0000-8
Chemical Name:	Dieldrin
CASRN:	60-57-1
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	145014
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	84	103	81	32	29
			90	101	96	36
			89	95	42	16
			97	101	91	31
Test Chemical	Dieldrin	5	76	61	89	39	39
			65	60	75	38	39
		10	75	61	46	20	27
			77	59	76	33	27
		20	58	34	51	29	32
			65	40	68	35	32
		30	80	34	72	30	32
			82	37	82	33	32
		40	66	11	65	33	30
			74	13	61	28	30
Positive Control	Methyl Methane Sulfonate	20	20	9	159	263	256*
			24	10	178	249	256*
	Methyl Methane Sulfonate	250	53	42	540	341	305*
			72	51	579	270	305*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	77	114	66	29	29
			81	104	61	25
			74	89	85	38
			72	93	56	26
Test Chemical	Dieldrin	10	58	59	66	38	48*
			76	66	132	58	48*
		20	59	35	106	60	75*
			55	44	148	89	75*
		30	58	25	196	113	147*
			34	17	181	180	147*
		40	37	5	576	524	420*
			49	10	463	317	420*
		50

Positive Control	Methyl Methane Sulfonate	15	23	19	175	250	218*
Positive Control			23	19	128	186	218*

Nonactivation Trial: 3 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	82	93	119	49	46
			82	111	93	38
			85	106	102	40
			71	90	124	58
Test Chemical	Dieldrin	5	77	76	124	54	49
			74	73	96	44	49
		10	82	73	120	49	42
			72	70	77	35	42
		20	74	43	124	56	58
			63	46	114	60	58
		30	57	19	175	103	106*
			48	17	156	109	106*
		40	39	4	316	274	268*
			36	5	284	263	268*
		50

Positive Control	Methyl Methane Sulfonate	15	48	30	335	233	234*
Positive Control			48	31	339	236	234*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination