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Study Information
Study Attribute Value
CEBS Accession Number: 002-02023-0001-0000-0
Chemical Name: Diethanolamine
CASRN: 111-42-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 095123_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 08/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 465 0.443 9.30 26.5 0.000
Test Chemical Diethanolamine 
150         
 50 1046 459 0.439 9.18 26.5 -1.007 
500         
 50 1046 487 0.466 9.74 26.5 5.032 
1500         
 50 1037 469 0.452 9.38 26.5 2.027
Positive Control Mitomycin-C 
 0.002     
 50 1044 727 0.696 14.54 26.5 57.093
Mitomycin-C 
 0.01      
 10 207 319 1.541 31.90 26.5 247.651
Trend: 0.593        
Probability: 0.277        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/07/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1006 518 0.515 10.36 25.5 0.000
Test Chemical Diethanolamine 
150         
 50 1018 505 0.496 10.10 25.5 -3.659 
500         
 50 1011 539 0.533 10.78 25.5 3.539 
1500         
 50 1003 565 0.563 11.30 25.5 9.400
Positive Control Cyclophosphamide 
 0.5       
 50 1016 1053 1.036 21.06 25.5 101.281
Cyclophosphamide 
2.5       
 10 201 592 2.945 59.20 25.5 471.997
Trend: 1.779        
Probability: 0.038