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Study Information
Study Attribute Value
CEBS Accession Number: 002-02027-0001-0000-4
Chemical Name: Diethyl phthalate
CASRN: 84-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 306322_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/25/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 316 0.302 6.32 26.0 0.000
Test Chemical Diethyl phthalate 
16         
 50 1039 378 0.364 7.56 26.0 20.426 
50         
 50 1048 384 0.366 7.68 26.0 21.287 
160         
 50 1042 381 0.366 7.62 28.0 21.032
Positive Control Triethylenemelamine 
 0.015     
 50 1033 1456 1.409 29.12 26.0 366.558
Trend: 2.364        
Probability: 0.009        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/25/1981    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 407 0.389 8.14 26.0 0.000
Test Chemical Diethyl phthalate 
50         
 50 1045 475 0.455 9.50 26.0 16.708 
160         
 50 1046 498 0.476 9.96 26.0 22.242 
500         
 50 1044 643 0.616 12.86 26.0 58.137
Positive Control Cyclophosphamide 
1         
 50 1046 1086 1.038 21.72 26.0 166.575
Trend: 7.270        
Probability: 0.000