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Study Information
Study Attribute Value
CEBS Accession Number: 002-02027-0002-0000-5
Chemical Name: Diethyl phthalate
CASRN: 84-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 306322_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 03/25/1981    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Diethyl phthalate 
50         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
160         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
500         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Positive Control: Triethylenemelamine 
 0.15      
 100 32 0.320 26.0 14 0.140 14.0 18 0.180 16.0 0 0.000 0.0
Trend: 1.718 1.340 1.358  
Probability: 0.043 0.090 0.087  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/25/1981    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: Diethyl phthalate 
50         
 100 5 0.050 3.0 0 0.000 0.0 5 0.050 3.0 0 0.000 0.0 
160         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
500         
 100 10 0.100 9.0 1 0.010 1.0 9 0.090 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 72 0.720 40.0 30 0.300 26.0 42 0.420 24.0 0 0.000 0.0
Trend: 2.416 1.270 2.103  
Probability: 0.008 0.102 0.018