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Study Information
Study Attribute Value
CEBS Accession Number: 002-02027-0003-0000-6
Chemical Name: Diethyl phthalate
CASRN: 84-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 913646_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1990    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1044 392 0.375 7.84 26.0 0.000
Negative (Not Specified)
0         
50 1044 367 0.352 7.34 26.0 -6.378
Test Chemical Diethyl phthalate
5         
50 1045 417 0.399 8.34 26.0 6.276
17         
50 1043 436 0.418 8.72 26.0 11.331
50         
50 1045 377 0.361 7.54 26.0 -3.919
167         
0 0 0 0.000 0.00 31.0 N/A
500         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1046 549 0.525 10.98 26.0 39.783
Mitomycin-C
 0.004     
10 210 182 0.867 18.20 26.0 130.816
Trend: -0.248        
Probability: 0.598        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1047 359 0.343 7.18 26.0 0.000
Negative (Not Specified)
0         
50 1044 367 0.352 7.34 26.0 2.522
Test Chemical Diethyl phthalate
50         
50 1044 412 0.395 8.24 26.0 15.093
167         
50 1045 465 0.445 9.30 26.0 29.774
500         
50 1043 588 0.564 11.76 26.0 64.416
1667         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.125     
50 1048 675 0.644 13.50 26.0 87.843
Cyclophosphamide
 0.5       
10 208 204 0.981 20.40 26.0 186.035
Trend: 7.765        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1990    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1050 445 0.424 8.90 31.0 0.000
Dimethyl Sulfoxide
0         
50 1048 395 0.377 7.90 26.0 -11.067
Test Chemical Diethyl phthalate
167         
50 1053 513 0.487 10.26 26.0 14.952
500         
50 1049 561 0.535 11.22 26.0 26.188
750         
50 1047 710 0.678 14.20 31.0 60.008
Positive Control Cyclophosphamide
 0.125     
50 1048 650 0.620 13.00 26.0 46.346
Cyclophosphamide
 0.5       
10 211 213 1.009 21.30 26.0 138.192
Trend: 7.631        
Probability: 0.000