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Study Information
Study Attribute Value
CEBS Accession Number: 002-02027-0003-0000-6
Chemical Name: Diethyl phthalate
CASRN: 84-66-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 913646_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/23/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 392 0.375 7.84 26.0 0.000
Negative (Not Specified) 
0         
 50 1044 367 0.352 7.34 26.0 -6.378
Test Chemical Diethyl phthalate 
5         
 50 1045 417 0.399 8.34 26.0 6.276 
17         
 50 1043 436 0.418 8.72 26.0 11.331 
50         
 50 1045 377 0.361 7.54 26.0 -3.919 
167         
 0 0 0 0.000 0.00 31.0 N/A 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 549 0.525 10.98 26.0 39.783
Mitomycin-C 
 0.004     
 10 210 182 0.867 18.20 26.0 130.816
Trend: -0.248        
Probability: 0.598        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/23/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 359 0.343 7.18 26.0 0.000
Negative (Not Specified) 
0         
 50 1044 367 0.352 7.34 26.0 2.522
Test Chemical Diethyl phthalate 
50         
 50 1044 412 0.395 8.24 26.0 15.093 
167         
 50 1045 465 0.445 9.30 26.0 29.774 
500         
 50 1043 588 0.564 11.76 26.0 64.416 
1667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1048 675 0.644 13.50 26.0 87.843
Cyclophosphamide 
 0.5       
 10 208 204 0.981 20.40 26.0 186.035
Trend: 7.765        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/13/1990    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 445 0.424 8.90 31.0 0.000
Dimethyl Sulfoxide 
0         
 50 1048 395 0.377 7.90 26.0 -11.067
Test Chemical Diethyl phthalate 
167         
 50 1053 513 0.487 10.26 26.0 14.952 
500         
 50 1049 561 0.535 11.22 26.0 26.188 
750         
 50 1047 710 0.678 14.20 31.0 60.008
Positive Control Cyclophosphamide 
 0.125     
 50 1048 650 0.620 13.00 26.0 46.346
Cyclophosphamide 
 0.5       
 10 211 213 1.009 21.30 26.0 138.192
Trend: 7.631        
Probability: 0.000