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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0001-0000-3
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 120506_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/09/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1041 386 0.371 7.72 26.0 0.000
Negative (Not Specified)
0         
50 1044 392 0.375 7.84 26.0 1.263
Test Chemical Diglycidyl resorcinol ether (DGRE)
 0.05      
50 1045 484 0.463 9.68 26.0 24.909
 0.16      
50 1038 503 0.485 10.06 26.0 30.688
 0.5       
50 1041 1504 1.445 30.08 26.0 289.637
1.6       
50 1045 3568 3.414 71.36 26.0 820.814
5         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1049 678 0.646 13.56 26.0 74.308
Mitomycin-C
 0.01      
50 1044 2364 2.264 47.28 26.0 510.675
Trend: 64.964        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 02/14/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1036 367 0.354 7.34 26.0 -18.124
Dimethyl Sulfoxide
0         
50 1047 453 0.433 9.06 26.0 0.000
Test Chemical Diglycidyl resorcinol ether (DGRE)
 0.05      
50 1033 420 0.407 8.40 26.0 -6.028
 0.16      
50 1035 1044 1.009 20.88 26.0 133.136
 0.5       
50 1037 2456 2.368 49.12 26.0 447.392
1.6       
0 0 0 0.000 0.00 26.0 N/A
5         
0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1029 1226 1.191 24.52 26.0 175.374
Mitomycin-C
 0.01      
10 206 556 2.699 55.60 26.0 523.815
Trend: 44.935        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/09/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1041 480 0.461 9.60 26.0 0.000
Negative (Not Specified)
0         
50 1045 514 0.492 10.28 26.0 6.673
Test Chemical Diglycidyl resorcinol ether (DGRE)
 0.5       
50 1046 490 0.468 9.80 26.0 1.595
1.6       
50 1029 507 0.493 10.14 26.0 6.857
5         
50 1025 634 0.619 12.68 26.0 34.145
16         
50 1045 2561 2.451 51.22 26.0 431.499
50         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
2         
50 1037 1073 1.035 21.46 26.0 124.404
Trend: 44.610        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/14/1984    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1042 468 0.449 9.36 26.0 0.000
Negative (Not Specified)
0         
50 1044 463 0.443 9.26 26.0 -1.258
Test Chemical Diglycidyl resorcinol ether (DGRE)
 0.5       
50 1046 424 0.405 8.48 26.0 -9.748
1.6       
50 1046 497 0.475 9.94 26.0 5.790
5         
50 1043 681 0.653 13.62 26.0 45.373
16         
50 1041 1937 1.861 38.74 26.0 314.286
50         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.3       
50 1040 532 0.512 10.64 26.0 13.894
Cyclophosphamide
2         
10 210 249 1.186 24.90 26.0 163.999
Trend: 35.780        
Probability: 0.000