Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02044-0001-0000-3 |
Chemical Name: | Diglycidyl resorcinol ether (DGRE) |
CASRN: | 101-90-6 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 120506_SCE |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
No Activation | 2 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
Induced Rat Liver S9 | 2_S9 | Positive |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1041 | 386 | 0.371 | 7.72 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1044 | 392 | 0.375 | 7.84 | 26.0 | 1.263 | |
Test Chemical | Diglycidyl resorcinol ether (DGRE) | 0.05 | 50 | 1045 | 484 | 0.463 | 9.68 | 26.0 | 24.909 |
0.16 | 50 | 1038 | 503 | 0.485 | 10.06 | 26.0 | 30.688 | ||
0.5 | 50 | 1041 | 1504 | 1.445 | 30.08 | 26.0 | 289.637 | ||
1.6 | 50 | 1045 | 3568 | 3.414 | 71.36 | 26.0 | 820.814 | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1049 | 678 | 0.646 | 13.56 | 26.0 | 74.308 |
Mitomycin-C | 0.01 | 50 | 1044 | 2364 | 2.264 | 47.28 | 26.0 | 510.675 | |
Trend: | 64.964 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Negative (Not Specified) | 0 | 50 | 1036 | 367 | 0.354 | 7.34 | 26.0 | -18.124 |
Dimethyl Sulfoxide | 0 | 50 | 1047 | 453 | 0.433 | 9.06 | 26.0 | 0.000 | |
Test Chemical | Diglycidyl resorcinol ether (DGRE) | 0.05 | 50 | 1033 | 420 | 0.407 | 8.40 | 26.0 | -6.028 |
0.16 | 50 | 1035 | 1044 | 1.009 | 20.88 | 26.0 | 133.136 | ||
0.5 | 50 | 1037 | 2456 | 2.368 | 49.12 | 26.0 | 447.392 | ||
1.6 | 0 | 0 | 0 | 0.000 | 0.00 | 26.0 | N/A | ||
5 | 0 | 0 | 0 | 0.000 | 0.00 | 31.0 | N/A | ||
Positive Control | Mitomycin-C | 0.001 | 50 | 1029 | 1226 | 1.191 | 24.52 | 26.0 | 175.374 |
Mitomycin-C | 0.01 | 10 | 206 | 556 | 2.699 | 55.60 | 26.0 | 523.815 | |
Trend: | 44.935 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1041 | 480 | 0.461 | 9.60 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1045 | 514 | 0.492 | 10.28 | 26.0 | 6.673 | |
Test Chemical | Diglycidyl resorcinol ether (DGRE) | 0.5 | 50 | 1046 | 490 | 0.468 | 9.80 | 26.0 | 1.595 |
1.6 | 50 | 1029 | 507 | 0.493 | 10.14 | 26.0 | 6.857 | ||
5 | 50 | 1025 | 634 | 0.619 | 12.68 | 26.0 | 34.145 | ||
16 | 50 | 1045 | 2561 | 2.451 | 51.22 | 26.0 | 431.499 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 2 | 50 | 1037 | 1073 | 1.035 | 21.46 | 26.0 | 124.404 |
Trend: | 44.610 | ||||||||
Probability: | 0.000 |
Dose µg/mL | Number Cells Examined | Number Chromosomes Examined | Total Number SCEs | SCE / Chromosome | SCE / Cell | Hours in BRDU | % Increase Over Solvent Control | ||
---|---|---|---|---|---|---|---|---|---|
Vehicle Control | Dimethyl Sulfoxide | 0 | 50 | 1042 | 468 | 0.449 | 9.36 | 26.0 | 0.000 |
Negative (Not Specified) | 0 | 50 | 1044 | 463 | 0.443 | 9.26 | 26.0 | -1.258 | |
Test Chemical | Diglycidyl resorcinol ether (DGRE) | 0.5 | 50 | 1046 | 424 | 0.405 | 8.48 | 26.0 | -9.748 |
1.6 | 50 | 1046 | 497 | 0.475 | 9.94 | 26.0 | 5.790 | ||
5 | 50 | 1043 | 681 | 0.653 | 13.62 | 26.0 | 45.373 | ||
16 | 50 | 1041 | 1937 | 1.861 | 38.74 | 26.0 | 314.286 | ||
50 | 0 | 0 | 0 | 0.000 | 0.00 | 0.0 | N/A | ||
Positive Control | Cyclophosphamide | 0.3 | 50 | 1040 | 532 | 0.512 | 10.64 | 26.0 | 13.894 |
Cyclophosphamide | 2 | 10 | 210 | 249 | 1.186 | 24.90 | 26.0 | 163.999 | |
Trend: | 35.780 | ||||||||
Probability: | 0.000 |