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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0002-0000-4
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 120506_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive* 
No Activation  2  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 02/16/1984    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Diglycidyl resorcinol ether (DGRE) 
 0.5       
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 
1.6       
 100 6 0.060 6.0 2 0.020 2.0 4 0.040 4.0 0 0.000 0.0 
5         
 100 66 0.660 40.0 28 0.280 22.0 28 0.280 21.0 10 0.100 1.0 
16         
 100 149 1.490 69.0 44 0.440 34.0 95 0.950 51.0 10 0.100 1.0 
25         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 17 0.170 14.0 9 0.090 7.0 8 0.080 8.0 0 0.000 0.0
Mitomycin-C 
1         
 50 29 0.580 48.0 15 0.300 28.0 14 0.280 28.0 0 0.000 0.0
Trend: 12.919 8.474 10.656  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 02/16/1984    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: Diglycidyl resorcinol ether (DGRE) 
5         
 100 5 0.050 5.0 1 0.010 1.0 3 0.030 3.0 1 0.010 1.0 
16         
 100 8 0.080 8.0 7 0.070 7.0 1 0.010 1.0 0 0.000 0.0 
25         
 100 7 0.070 6.0 3 0.030 3.0 4 0.040 4.0 0 0.000 0.0 
50         
 100 33 0.330 27.0 16 0.160 14.0 17 0.170 15.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 25 0.250 21.0 15 0.150 12.0 10 0.100 10.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 27 0.540 40.0 14 0.280 22.0 13 0.260 22.0 0 0.000 0.0
Trend: 4.977 4.012 3.912  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 01/18/1984    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Diglycidyl resorcinol ether (DGRE) 
 0.5       
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1.6       
 100 4 0.040 4.0 3 0.030 3.0 1 0.010 1.0 0 0.000 0.0 
5         
 100 17 0.170 14.0 7 0.070 6.0 10 0.100 9.0 0 0.000 0.0 
16         
 100 153 1.530 61.0 46 0.460 32.0 64 0.640 38.0 43 0.430 7.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.25      
 100 33 0.330 26.0 11 0.110 11.0 22 0.220 17.0 0 0.000 0.0
Mitomycin-C 
1         
 50 25 0.500 44.0 12 0.240 22.0 13 0.260 24.0 0 0.000 0.0
Trend: 10.969 7.871 8.257  
Probability: 0.000 0.000 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/17/1984    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: Diglycidyl resorcinol ether (DGRE) 
5         
 100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 
16         
 100 12 0.120 10.0 4 0.040 4.0 8 0.080 8.0 0 0.000 0.0 
50         
 100 99 0.990 58.0 42 0.420 34.0 57 0.570 37.0 0 0.000 0.0 
160         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 100 14 0.140 13.0 4 0.040 4.0 10 0.100 9.0 0 0.000 0.0
Cyclophosphamide 
50         
 50 32 0.640 36.0 11 0.220 20.0 11 0.220 22.0 10 0.200 1.0
Trend: 9.880 7.128 7.969  
Probability: 0.000 0.000 0.000