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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0014-0000-7
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 195111
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 91 122 166 61 60
    68 97 117 58
    63 92 119 63
    73 89 127 58
Test Chemical Diglycidyl resorcinol ether (DGRE) 
 0.25      
 73 59 736 335 339*
    65 58 662 342
  
 0.5       
 33 28 770 790 783*
    30 23 703 777
  
1         
 10r 5 234 793 761*
    13 5 277 729
  
2         
 2r 0 39 709
    1r 0 28 1120
  
4         
   
Positive Control Methyl Methane Sulfonate 
15         
 43 33 221 172 187*
    38 31 227 202

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 102 95 113 37 35
    127r 109 128 34
    111 105 110 33
    128r 116 190 49
Test Chemical Diglycidyl resorcinol ether (DGRE) 
 0.125     
 102 79 541 177 187*
    88 65 515 196
  
 0.25      
 61 49 670 368 369*
    67 46 744 370
  
 0.5       
 37 22 788 710 689*
    32 21 644 667
  
1         
 10r 2 236 800 981*
    10r 2 343 1163
  
2         
 3r 0 21 262
    1r 0 24 600
  
4         
  
8         
   
Positive Control Methyl Methane Sulfonate 
15         
 67 44 284 142 124*
    70 39 223 106

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination