Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02044-0014-0000-7
Chemical Name:	Diglycidyl resorcinol ether (DGRE)
CASRN:	101-90-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	195111
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	91	122	166	61	60
			68	97	117	58
			63	92	119	63
			73	89	127	58
Test Chemical	Diglycidyl resorcinol ether (DGRE)	0.25	73	59	736	335	339*
			65	58	662	342	339*
		0.5	33	28	770	790	783*
			30	23	703	777	783*
		1	10r	5	234	793	761*
			13	5	277	729	761*
		2	2r	0	39	709
			1r	0	28	1120
		4

Positive Control	Methyl Methane Sulfonate	15	43	33	221	172	187*
Positive Control			38	31	227	202	187*

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Sulfoxide	0	102	95	113	37	35
			127r	109	128	34
			111	105	110	33
			128r	116	190	49
Test Chemical	Diglycidyl resorcinol ether (DGRE)	0.125	102	79	541	177	187*
			88	65	515	196	187*
		0.25	61	49	670	368	369*
			67	46	744	370	369*
		0.5	37	22	788	710	689*
			32	21	644	667	689*
		1	10r	2	236	800	981*
			10r	2	343	1163	981*
		2	3r	0	21	262
			1r	0	24	600
		4
		8

Positive Control	Methyl Methane Sulfonate	15	67	44	284	142	124*
Positive Control			70	39	223	106	124*

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination