Genetic Toxicology - Rodent Cytogenetics

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02044-0015-0000-8
Chemical Name:	Diglycidyl resorcinol ether (DGRE)
CASRN:	101-90-6
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	389996_SCE
Study Result:	Positive

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Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.

Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	01/29/86	17	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 17 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	4.21 ± 0.508
Test Chemical	Diglycidyl resorcinol ether (DGRE)	62.5	4	4.46 ± 0.457
		125	4	4.61 ± 0.710
		250	4	7.59 ± 0.671
Positive Control	Dimethylbenzanthracene	100	4	11.63 ± 0.647

Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type	Start Date	Sample Time (h)	Species	Sex	Strain	Tissue	Protocol	Trend Test P
SCE	02/06/86	23	Mouse	Male	B6C3F1	Bone Marrow	IP/IJ x 1, 23 hour

		Dose (mg/kg)	n	SCE / Cell (Mean ± SEM)
Vehicle Control	Dimethyl Sulfoxide	0	4	4.25 ± 0.398
Test Chemical	Diglycidyl resorcinol ether (DGRE)	62.5	4	5.72 ± 0.613
		125	4	7.57 ± 0.733
		250	4	16.75 ± 2.149
Positive Control	Dimethylbenzanthracene	2.5	4	7.82 ± 0.612

Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed