COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0017-0000-0
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 873378_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/02/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 5.07 ± 0.296
Test Chemical Diglycidyl resorcinol ether (DGRE)
125         
4 5.75 ± 0.295
 
250         
4 5.80 ± 0.454
 
500         
4 10.87 ± 1.515
Positive Control Dimethylbenzanthracene
2.5       
4 10.80 ± 0.764


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/15/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
4 3.91 ± 0.465
Test Chemical Diglycidyl resorcinol ether (DGRE)
125         
4 4.38 ± 0.278
 
250         
4 4.12 ± 0.099
 
500         
4 3.81 ± 0.255
Positive Control Dimethylbenzanthracene
2.5       
4 8.92 ± 1.084


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/21/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)
n SCE / Cell
(Mean ± SEM)
Pairwise P
Vehicle Control Corn Oil
 0         
5 5.06 ± 0.352
Test Chemical Diglycidyl resorcinol ether (DGRE)
500         
4 7.60 ± 1.194
Positive Control Dimethylbenzanthracene
2.5       
4 9.01 ± 0.782


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed