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Study Information
Study Attribute Value
CEBS Accession Number: 002-02044-0017-0000-0
Chemical Name: Diglycidyl resorcinol ether (DGRE)
CASRN: 101-90-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 873378_SCE
Study Result: Positive


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 10/02/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 5.07 ± 0.296
Test Chemical Diglycidyl resorcinol ether (DGRE) 
125         
 4 5.75 ± 0.295
  
250         
 4 5.80 ± 0.454
  
500         
 4 10.87 ± 1.515
Positive Control Dimethylbenzanthracene 
2.5       
 4 10.80 ± 0.764


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/15/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 3.91 ± 0.465
Test Chemical Diglycidyl resorcinol ether (DGRE) 
125         
 4 4.38 ± 0.278
  
250         
 4 4.12 ± 0.099
  
500         
 4 3.81 ± 0.255
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.92 ± 1.084


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/21/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 5 5.06 ± 0.352
Test Chemical Diglycidyl resorcinol ether (DGRE) 
500         
 4 7.60 ± 1.194
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.01 ± 0.782


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed