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Study Information
Study Attribute Value
CEBS Accession Number: 002-02057-0001-0000-7
Chemical Name: Dimethoate
CASRN: 60-51-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 171898_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/16/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 487 0.466 9.74 26.0 0.000
Test Chemical Dimethoate 
50         
 50 1050 578 0.550 11.56 26.0 18.234 
160         
 50 1051 916 0.872 18.32 26.0 87.196 
500         
 25 524 962 1.836 38.48 26.0 294.318
Positive Control Mitomycin-C 
 0.005     
 25 522 595 1.140 23.80 26.0 144.821
Trend: 26.975        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/16/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 465 0.444 9.30 26.0 0.000
Test Chemical Dimethoate 
500         
 50 1045 484 0.463 9.68 26.0 4.285 
1600         
 50 1046 614 0.587 12.28 26.0 32.169 
5000         
 25 525 823 1.568 32.92 26.0 252.967
Positive Control Cyclophosphamide 
1         
 50 1047 873 0.834 17.46 26.0 87.742
Trend: 22.020        
Probability: 0.000