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Study Information
Study Attribute Value
CEBS Accession Number: 002-02057-0002-0000-8
Chemical Name: Dimethoate
CASRN: 60-51-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 171898_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Questionable 

Trial #:1   Activation: No Activation    Date: 03/16/1983    Harvest Time: 14 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Dimethoate 
160         
 100 6 0.060 5.0 1 0.010 1.0 5 0.050 5.0 0 0.000 0.0 
500         
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 5.0 0 0.000 0.0 
1600         
 100 13 0.130 12.0 4 0.040 4.0 9 0.090 9.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 42 0.420 29.0 14 0.140 11.0 28 0.280 22.0 0 0.000 0.0
Trend: 2.587 2.235 1.768  
Probability: 0.005 0.013 0.039  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/16/1983    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: Dimethoate 
500         
 100 8 0.080 7.0 1 0.010 1.0 7 0.070 6.0 0 0.000 0.0 
1600         
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 5.0 0 0.000 0.0 
5000         
 100 12 0.120 12.0 4 0.040 4.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 19 0.380 30.0 7 0.140 14.0 12 0.240 20.0 0 0.000 0.0
Trend: 2.035 1.596 1.371  
Probability: 0.021 0.055 0.085