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Study Information
Study Attribute Value
CEBS Accession Number: 002-02058-0001-0000-8
Chemical Name: Dimethoxane
CASRN: 828-00-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 028235_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 06/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1055 506 0.480 10.12 25.7 0.000
Test Chemical Dimethoxane 
 0.36      
 50 1054 574 0.545 11.48 25.7 13.546 
1.1       
 50 1046 611 0.584 12.22 25.7 21.790 
3.66      
 50 1049 1621 1.545 32.42 25.7 222.188 
11         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1038 637 0.614 12.74 25.7 27.951
Mitomycin-C 
 0.02      
 5 105 194 1.848 38.80 25.7 285.225
Trend: 26.697        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/12/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 511 0.491 10.22 26.2 0.000
Test Chemical Dimethoxane 
7.6       
 50 1048 1303 1.243 26.06 26.2 153.044 
10.1       
 50 1048 1620 1.546 32.40 26.2 214.605 
12.6       
 50 1059 2285 2.158 45.70 33.2 339.140 
15.1       
 0 0 0 0.000 0.00 33.2 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 592 0.565 11.84 26.2 14.967
Mitomycin-C 
 0.01      
 5 101 198 1.960 39.60 26.2 298.985
Trend: 32.629        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/21/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 502 0.480 10.04 25.7 0.000
Test Chemical Dimethoxane 
11         
 50 1046 621 0.594 12.42 25.7 23.587 
36.6       
 50 1053 1000 0.950 20.00 25.7 97.690 
110         
 50 1046 1476 1.411 29.52 33.5 193.743 
366.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1054 816 0.774 16.32 25.7 61.162
Cyclophosphamide 
2         
 5 105 208 1.981 41.60 25.7 312.370
Trend: 24.491        
Probability: 0.000