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Study Information
Study Attribute Value
CEBS Accession Number: 002-02058-0002-0000-9
Chemical Name: Dimethoxane
CASRN: 828-00-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 028235_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 07/21/1983    Harvest Time: 22 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0
Test Chemical: Dimethoxane 
12.6       
 100 5 0.050 5.0 3 0.030 3.0 1 0.010 1.0 1 0.010 1.0 
15.1       
 100 23 0.230 20.0 17 0.170 17.0 5 0.050 3.0 1 0.010 1.0 
17.6       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
20.2       
 25 214 8.560 100.0 2 0.080 8.0 2 0.080 8.0 210 8.400 84.0 
22.7       
 10 82 8.200 100.0 0 0.000 0.0 0 0.000 0.0 82 8.200 100.0
Positive Control: Mitomycin-C 
 0.04      
 50 19 0.380 22.0 12 0.240 18.0 7 0.140 8.0 0 0.000 0.0
Trend: 11.709 2.371 1.734  
Probability: 0.000 0.009 0.041  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 07/12/1983    Harvest Time: 21.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 7 0.070 4.0 2 0.020 2.0 4 0.040 2.0 1 0.010 1.0
Test Chemical: Dimethoxane 
126         
 100 9 0.090 9.0 4 0.040 4.0 2 0.020 2.0 3 0.030 3.0 
148         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
176         
 50 90 1.800 76.0 59 1.180 36.0 30 0.600 40.0 1 0.020 2.0 
198         
 50 88 1.760 74.0 64 1.280 66.0 24 0.480 32.0 0 0.000 0.0 
252         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
12.5       
 50 21 0.420 26.0 8 0.160 10.0 13 0.260 20.0 0 0.000 0.0
Trend: 11.804 10.088 7.548  
Probability: 0.000 0.000 0.000