Genetic Toxicology - Rodent Cytogenetics

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Study Information
Study Attribute	Value
CEBS Accession Number:	002-02062-0012-0000-5
Chemical Name:	Dimethyl hydrogen phosphite
CASRN:	868-85-9
NTP Study Type:	Genetic Toxicology - Rodent Cytogenetics
NTP Study ID:	515672_CA
Study Result:	Positive (Nonstandard Protocol)

View Study Details | View Protocol | Download To Excel


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	06/13/89	36	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 36 hour	0.0318

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Positive Control	Mitomycin-C	1	8	13.00 ± 2.04	0.0000
Test Chemical	Dimethyl hydrogen phosphite	500	8	2.75 ± 0.92	0.1101
		1000	8	2.75 ± 0.75	0.1101
		2000	8	3.75 ± 1.03	0.0233
Vehicle Control	No Stressor	0	8	1.50 ± 0.82	0.0000


Test Type	Start Date	Sample Time (h)	Species	Sex	Tissue	Protocol	Trend Test P
CA	08/22/89	17	Mouse	Male	Bone Marrow	Intraperitoneal Injection x 1/study, 17 hour	0.0012

Test Group		Dose (mg/kg)	n	Percent Cells w/ Aberrations (Mean ± SEM)	Pairwise P
Positive Control	Mitomycin-C	1	8	11.25 ± 1.36	0.0000
Test Chemical	Dimethyl hydrogen phosphite	500	8	3.00 ± 0.85	0.3327
		1000	8	3.75 ± 0.80	0.1548
		2000	7	6.57 ± 1.43	0.0033
Vehicle Control	No Stressor	0	8	2.50 ± 0.91	0.0000

Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed