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Study Information
Study Attribute Value
CEBS Accession Number: 002-02062-0012-0000-5
Chemical Name: Dimethyl hydrogen phosphite
CASRN: 868-85-9
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 515672_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/13/89 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0318
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 13.00 ± 2.04 0.0000
Test Chemical Dimethyl hydrogen phosphite 
500         
 8 2.75 ± 0.92 0.1101
  
1000         
 8 2.75 ± 0.75 0.1101
  
2000         
 8 3.75 ± 1.03 0.0233
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.82 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/22/89 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0012
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 11.25 ± 1.36 0.0000
Test Chemical Dimethyl hydrogen phosphite 
500         
 8 3.00 ± 0.85 0.3327
  
1000         
 8 3.75 ± 0.80 0.1548
  
2000         
 7 6.57 ± 1.43 0.0033
Vehicle Control No Stressor 
 0         
 8 2.50 ± 0.91 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed