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Study Information
Study Attribute Value
CEBS Accession Number: 002-02063-0001-0000-4
Chemical Name: Dimethyl methylphosphonate
CASRN: 756-79-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 202021_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/13/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1034 375 0.363 7.50 26.5 0.000
Negative (Not Specified) 
0         
 50 1038 423 0.408 8.46 26.5 12.365
Test Chemical Dimethyl methylphosphonate 
160         
 50 1032 370 0.359 7.40 26.5 -1.142 
500         
 50 1038 446 0.430 8.92 26.5 18.475 
1600         
 50 1039 580 0.558 11.60 26.5 53.922 
5000         
 50 1036 884 0.853 17.68 26.5 135.278
Positive Control Mitomycin-C 
 0.01      
 50 1042 2461 2.362 49.22 26.5 551.228
Trend: 16.781        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 03/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1038 360 0.347 7.20 26.0 -5.221
Medium 
0         
 50 1033 378 0.366 7.56 26.0 0.000
Test Chemical Dimethyl methylphosphonate 
2000         
 50 1038 580 0.559 11.60 26.0 52.700 
3000         
 50 1031 679 0.659 13.58 26.0 79.978 
4000         
 50 1003 729 0.727 14.58 26.0 98.626 
5000         
 50 1023 845 0.826 16.90 26.0 125.730
Positive Control Mitomycin-C 
 0.005     
 50 1039 1301 1.252 26.02 26.0 242.192
Trend: 13.968        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/13/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1039 329 0.317 6.58 26.5 -13.851
Medium 
0         
 50 1042 383 0.368 7.66 26.5 0.000
Test Chemical Dimethyl methylphosphonate 
160         
 50 1049 376 0.358 7.52 26.5 -2.483 
500         
 50 1046 393 0.376 7.86 26.5 2.219 
1600         
 50 1052 415 0.394 8.30 26.5 7.325 
5000         
 50 1048 401 0.383 8.02 26.5 4.100
Positive Control Cyclophosphamide 
1.5       
 50 1052 1123 1.067 22.46 26.5 190.424
Trend: 1.108        
Probability: 0.134        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/19/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1034 360 0.348 7.20 26.0 -16.823
Medium 
0         
 50 1044 437 0.419 8.74 26.0 0.000
Test Chemical Dimethyl methylphosphonate 
2000         
 50 1029 447 0.434 8.94 26.0 3.779 
3000         
 50 1027 409 0.398 8.18 26.0 -4.858 
4000         
 50 1045 397 0.380 7.94 26.0 -9.240 
5000         
 50 1028 435 0.423 8.70 26.0 1.092
Positive Control Cyclophosphamide 
1.5       
 50 1042 1430 1.372 28.60 26.0 227.859
Trend: -0.896        
Probability: 0.815