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Study Information
Study Attribute Value
CEBS Accession Number: 002-02063-0003-0000-6
Chemical Name: Dimethyl methylphosphonate
CASRN: 756-79-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 314062_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 01/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1021 383 0.375 7.66 25.5 0.000
Test Chemical Dimethyl methylphosphonate 
1100         
 50 1034 402 0.389 8.04 25.5 3.641 
3670         
 50 1031 679 0.659 13.58 25.5 75.565 
11000         
 50 1024 1365 1.333 27.30 25.5 255.353
Positive Control Mitomycin-C 
 0.001     
 50 1040 545 0.524 10.90 25.5 39.698
Mitomycin-C 
 0.01      
 5 104 202 1.942 40.40 25.5 417.780
Trend: 26.963        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/19/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1035 420 0.406 8.40 25.5 0.000
Test Chemical Dimethyl methylphosphonate 
1100         
 50 1031 403 0.391 8.06 25.5 -3.675 
3670         
 50 1036 409 0.395 8.18 25.5 -2.713 
11000         
 50 1036 504 0.486 10.08 25.5 19.884
Positive Control Cyclophosphamide 
 0.3       
 50 1040 628 0.604 12.56 25.5 48.805
Cyclophosphamide 
2         
 5 103 129 1.252 25.80 25.5 208.634
Trend: 2.694        
Probability: 0.004        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/08/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1033 409 0.396 8.18 25.5 0.000
Test Chemical Dimethyl methylphosphonate 
14300         
 50 1019 515 0.505 10.30 25.5 27.647 
17600         
 50 1037 617 0.595 12.34 25.5 50.274 
22000         
 50 1032 624 0.605 12.48 25.5 52.715
Positive Control Cyclophosphamide 
 0.3       
 50 1031 564 0.547 11.28 25.5 38.165
Cyclophosphamide 
2         
 5 103 104 1.010 20.80 25.5 155.019
Trend: 7.073        
Probability: 0.000