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Study Information
Study Attribute Value
CEBS Accession Number: 002-02064-0001-0000-5
Chemical Name: Dimethyl morpholinophosphoramidate
CASRN: 597-25-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 499883_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Weakly Positive 
No Activation  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/13/1983    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1050 434 0.413 8.68 25.0 -5.304
Medium
0         
50 1047 457 0.436 9.14 25.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate
50         
50 1047 435 0.415 8.70 24.5 -4.814
160         
50 1042 509 0.488 10.18 24.5 11.913
500         
50 1048 521 0.497 10.42 24.5 13.896
1600         
50 1045 546 0.522 10.92 24.5 19.703
5000         
50 1045 838 0.802 16.76 24.5 83.721
Positive Control Mitomycin-C
 0.003     
50 1047 1074 1.026 21.48 25.0 135.011
Trend: 11.470        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/14/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1040 409 0.393 8.18 26.0 8.123
Medium
0         
50 1042 379 0.364 7.58 26.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate
1000         
50 1046 520 0.497 10.40 26.0 36.678
1600         
50 1046 637 0.609 12.74 26.0 67.431
3000         
50 1052 763 0.725 15.26 26.0 99.406
4000         
50 1044 794 0.761 15.88 26.0 109.097
5000         
50 1047 1061 1.013 21.22 31.0 178.610
Positive Control Mitomycin-C
 0.005     
50 1040 1250 1.202 25.00 26.0 230.450
Mitomycin-C
 0.005     
50 1036 1256 1.212 25.12 26.0 233.318
Trend: 19.255        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/23/1983    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1040 383 0.368 7.66 26.0 -10.094
Medium
0         
50 1040 426 0.410 8.52 26.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate
1600         
50 1044 493 0.472 9.86 26.0 15.284
3000         
50 1036 488 0.471 9.76 26.0 14.996
4000         
50 1036 470 0.454 9.40 26.0 10.755
5000         
50 1042 478 0.459 9.56 26.0 11.991
Positive Control Cyclophosphamide
1.5       
50 1049 1067 1.017 21.34 26.0 148.321
Cyclophosphamide
1.5       
50 1042 1245 1.195 24.90 26.0 191.693
Trend: 1.311        
Probability: 0.095