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Study Information
Study Attribute Value
CEBS Accession Number: 002-02064-0001-0000-5
Chemical Name: Dimethyl morpholinophosphoramidate
CASRN: 597-25-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 499883_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/13/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1050 434 0.413 8.68 25.0 -5.304
Medium 
0         
 50 1047 457 0.436 9.14 25.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate 
50         
 50 1047 435 0.415 8.70 24.5 -4.814 
160         
 50 1042 509 0.488 10.18 24.5 11.913 
500         
 50 1048 521 0.497 10.42 24.5 13.896 
1600         
 50 1045 546 0.522 10.92 24.5 19.703 
5000         
 50 1045 838 0.802 16.76 24.5 83.721
Positive Control Mitomycin-C 
 0.003     
 50 1047 1074 1.026 21.48 25.0 135.011
Trend: 11.470        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/14/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 409 0.393 8.18 26.0 8.123
Medium 
0         
 50 1042 379 0.364 7.58 26.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate 
1000         
 50 1046 520 0.497 10.40 26.0 36.678 
1600         
 50 1046 637 0.609 12.74 26.0 67.431 
3000         
 50 1052 763 0.725 15.26 26.0 99.406 
4000         
 50 1044 794 0.761 15.88 26.0 109.097 
5000         
 50 1047 1061 1.013 21.22 31.0 178.610
Positive Control Mitomycin-C 
 0.005     
 50 1040 1250 1.202 25.00 26.0 230.450
Mitomycin-C 
 0.005     
 50 1036 1256 1.212 25.12 26.0 233.318
Trend: 19.255        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/23/1983    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1040 383 0.368 7.66 26.0 -10.094
Medium 
0         
 50 1040 426 0.410 8.52 26.0 0.000
Test Chemical Dimethyl morpholinophosphoramidate 
1600         
 50 1044 493 0.472 9.86 26.0 15.284 
3000         
 50 1036 488 0.471 9.76 26.0 14.996 
4000         
 50 1036 470 0.454 9.40 26.0 10.755 
5000         
 50 1042 478 0.459 9.56 26.0 11.991
Positive Control Cyclophosphamide 
1.5       
 50 1049 1067 1.017 21.34 26.0 148.321
Cyclophosphamide 
1.5       
 50 1042 1245 1.195 24.90 26.0 191.693
Trend: 1.311        
Probability: 0.095