Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02064-0010-0000-5 |
Chemical Name: | Dimethyl morpholinophosphoramidate |
CASRN: | 597-25-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 652921 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 39r | 72 | 45 | 39 | 39 |
51 | 86 | 57 | 38 | ||||
39r | 56 | 35 | 30 | ||||
90 | 114 | 107 | 40 | ||||
Test Chemical | Dimethyl morpholinophosphoramidate | 0.125 | 47 | 78 | 69 | 49 | 51 |
37 | 53 | 50 | 45 | ||||
46 | 64 | 82 | 59 | ||||
0.25 | 76 | 137 | 104 | 46 | 45 | ||
43 | 102 | 57 | 44 | ||||
0.5 | 46 | 76 | 65 | 47 | 45 | ||
49 | 83 | 54 | 37 | ||||
51 | 74 | 80 | 52 | ||||
1 | 52 | 87 | 59 | 38 | 51 | ||
55 | 43 | 96 | 58 | ||||
55 | 70 | 94 | 57 | ||||
2 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 28 | 42 | 201 | 242 | 336* |
25 | 44 | 259 | 348 | ||||
27 | 25 | 344 | 420 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 94 | 138 | 140 | 50 | 54 |
79 | 95 | 108 | 45 | ||||
71 | 70 | 133 | 63 | ||||
93 | 97 | 158 | 57 | ||||
Test Chemical | Dimethyl morpholinophosphoramidate | 0.25 | 68# | 85 | 137 | 67 | 67 |
70 | 102 | 138 | 66 | ||||
71 | 91 | 144 | 67 | ||||
0.375 | 84 | 77 | 173 | 69 | 65 | ||
72 | 91 | 136 | 63 | ||||
89 | 101 | 170 | 64 | ||||
0.5 | 50 | 75 | 115 | 76 | 68 | ||
88# | 98 | 159 | 61 | ||||
71 | 103 | 142 | 67 | ||||
0.75 | 80 | 93 | 163 | 68 | 71 | ||
87 | 78 | 169 | 65 | ||||
72 | 85 | 174 | 81 | ||||
1 | 73 | 75 | 155 | 71 | 74 | ||
79 | 76 | 202 | 86 | ||||
70 | 48 | 137 | 65 | ||||
1.5 | 84 | 73 | 189 | 75 | 83* | ||
58 | 66 | 140 | 81 | ||||
91 | 64 | 251 | 92 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 28 | 13 | 605 | 733 | 722* |
26 | 16 | 527 | 684 | ||||
26 | 10 | 576 | 748 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 83 | 110 | 75 | 30 | 35 |
74 | 88 | 86 | 39 | ||||
104 | 90 | 146 | 47 | ||||
106 | 112 | 80 | 25 | ||||
Test Chemical | Dimethyl morpholinophosphoramidate | 0.5 | 68 | 80 | 72 | 35 | 32 |
75 | 97 | 64 | 28 | ||||
89 | 74 | 87 | 33 | ||||
0.75 | 73 | 91 | 94 | 43 | 46 | ||
58 | 96 | 84 | 48 | ||||
76 | 73 | 105 | 46 | ||||
1 | 107 | 97 | 131 | 41 | 39 | ||
96 | 66 | 93 | 32 | ||||
69 | 106 | 93 | 45 | ||||
1.5 | 75 | 117 | 80 | 36 | 47 | ||
116 | 78 | 149 | 43 | ||||
55 | 69 | 101 | 62 | ||||
1.8 | 68 | 89 | 110 | 54 | 54* | ||
93 | 23 | 171 | 61 | ||||
78 | 113 | 113 | 48 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 53 | 58 | 537 | 339 | 287* |
61 | 75 | 490 | 268 | ||||
52 | 73 | 398 | 254 |
Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 106 | 74 | 167 | 53 | 39 |
113 | 115 | 136 | 40 | ||||
109 | 107 | 104 | 32 | ||||
92 | 103 | 92 | 34 | ||||
Test Chemical | Dimethyl morpholinophosphoramidate | 1400 | 84 | 50 | 154 | 61 | 54 |
93 | 57 | 141 | 51 | ||||
105 | 79 | 158 | 50 | ||||
1600 | 74 | 46 | 157 | 71 | 59* | ||
89 | 59 | 135 | 51 | ||||
80 | 40 | 136 | 56 | ||||
1800 | 106 | 50 | 143 | 45 | 71* | ||
85 | 23 | 196 | 77 | ||||
75 | 47 | 206 | 92 | ||||
1900 | 101 | 32 | 317 | 105 | 102* | ||
95 | 43 | 211 | 74 | ||||
75 | 28 | 288 | 128 | ||||
2000 | 105 | 48 | 287 | 91 | 85* | ||
96 | 49 | 201 | 70 | ||||
89 | 50 | 253 | 95 | ||||
2200 | 95 | 10 | 331 | 116 | 90* | ||
106 | 64 | 189 | 59 | ||||
92 | 49 | 262 | 95 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 118 | 81 | 663 | 187 | 237* |
95 | 67 | 676 | 237 | ||||
79 | 45 | 683 | 287 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 | 105 | 91 | 151 | 48 | 41 |
108 | 99 | 143 | 44 | ||||
98 | 99 | 114 | 39 | ||||
115 | 111 | 112 | 32 | ||||
Test Chemical | Dimethyl morpholinophosphoramidate | 0.25 | 77 | 79 | 80 | 35 | 29 |
86 | 117 | 64 | 25 | ||||
78 | 81 | 62 | 26 | ||||
0.5 | 99 | 104 | 82 | 28 | 27 | ||
83 | 99 | 69 | 28 | ||||
80# | 95 | 60 | 25 | ||||
0.75 | 99 | 78 | 109 | 37 | 30 | ||
103 | 96 | 66 | 21 | ||||
90 | 70 | 84 | 31 | ||||
1 | 86# | 70 | 62 | 24 | 30 | ||
109 | 93 | 110 | 34 | ||||
98 | 115 | 96 | 33 | ||||
1.5 | 100 | 128 | 91 | 30 | 31 | ||
111 | 98 | 118 | 36 | ||||
96 | 90 | 75 | 26 | ||||
2 | 116 | 113 | 190 | 55 | 46 | ||
97 | 67 | 151 | 52 | ||||
72 | 93 | 65 | 30 | ||||
Positive Control | 3-Methylcholanthrene | 2.5 | 77 | 46 | 634 | 275 | 351* |
31# | 6 | 526 | 575 | ||||
103 | 54 | 625 | 203 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination