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Study Information
Study Attribute Value
CEBS Accession Number: 002-02065-0001-0000-6
Chemical Name: Dimethyl phthalate
CASRN: 131-11-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 970550_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Questionable 
Induced Rat Liver S9  2_S9  Weakly Positive 
Induced Rat Liver S9  3_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 04/29/1986    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 372 0.363 7.44 26.5 0.000
Test Chemical Dimethyl phthalate 
50         
 50 1037 369 0.356 7.38 26.5 -1.954 
151         
 50 1030 388 0.377 7.76 26.5 3.795 
500         
 50 1039 407 0.392 8.14 26.5 7.934 
1510         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1036 585 0.565 11.70 26.5 55.588
Mitomycin-C 
 0.01      
 10 208 222 1.067 22.20 26.5 194.083
Trend: 1.269        
Probability: 0.102        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/29/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 437 0.421 8.74 26.0 0.000
Test Chemical Dimethyl phthalate 
151         
 50 1045 528 0.505 10.56 26.0 20.130 
500         
 50 1040 465 0.447 9.30 26.0 6.305 
1510         
 50 1045 413 0.395 8.26 26.0 -6.035 
5010         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1047 605 0.578 12.10 26.0 37.386
Cyclophosphamide 
2.5       
 10 210 285 1.357 28.50 26.0 222.671
Trend: -1.444        
Probability: 0.926        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 06/11/1986    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 424 0.405 8.48 26.0 0.000
Test Chemical Dimethyl phthalate 
248         
 50 1036 410 0.396 8.20 26.0 -2.275 
414         
 50 1047 478 0.457 9.56 26.0 12.736 
1240         
 50 1050 530 0.505 10.60 26.0 24.643
Positive Control Cyclophosphamide 
 0.5       
 50 1046 1008 0.964 20.16 26.0 137.963
Cyclophosphamide 
2.5       
 10 209 589 2.818 58.90 26.0 595.905
Trend: 3.903        
Probability: 0.000        

Trial #: 3_S9    Activation: Induced Rat Liver S9    Date: 06/24/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 428 0.408 8.56 26.0 0.000
Test Chemical Dimethyl phthalate 
494         
 50 1050 402 0.383 8.04 26.0 -6.254 
988         
 50 1045 503 0.481 10.06 26.0 17.861 
1980         
 50 1047 540 0.516 10.80 26.0 26.289 
2960         
 50 1042 562 0.539 11.24 26.0 32.065 
3950         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1051 674 0.641 13.48 26.0 57.027
Cyclophosphamide 
2.5       
 10 210 382 1.819 38.20 26.0 345.412
Trend: 6.031        
Probability: 0.000