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Study Information
Study Attribute Value
CEBS Accession Number: 002-02065-0002-0000-7
Chemical Name: Dimethyl phthalate
CASRN: 131-11-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 970550_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 05/08/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: Dimethyl phthalate 
150         
 200 5 0.025 1.0 1 0.005 0.5 4 0.020 1.0 0 0.000 0.0 
498         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
1500         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.75      
 200 30 0.150 10.5 10 0.050 5.0 20 0.100 8.0 0 0.000 0.0
Mitomycin-C 
5         
 50 18 0.360 26.0 9 0.180 18.0 9 0.180 16.0 0 0.000 0.0
Trend: -1.518 -1.274 -1.087  
Probability: 0.935 0.899 0.862  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 05/08/1986    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 11 0.055 5.0 4 0.020 2.0 5 0.025 2.0 2 0.010 2.0
Test Chemical: Dimethyl phthalate 
498         
 200 11 0.055 5.5 1 0.005 0.5 10 0.050 5.0 0 0.000 0.0 
1500         
 200 14 0.070 6.5 5 0.025 2.5 8 0.040 4.0 1 0.005 1.0 
4980         
 200 21 0.105 8.5 10 0.050 4.5 11 0.055 4.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 50 57 1.140 46.0 12 0.240 20.0 25 0.500 32.0 20 0.400 2.0
Trend: 1.493 1.979 1.068  
Probability: 0.068 0.024 0.143  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/16/1986    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 5 0.025 2.0 1 0.005 0.5 3 0.015 1.5 1 0.005 1.0
Test Chemical: Dimethyl phthalate 
3060         
 200 7 0.035 3.0 5 0.025 2.0 1 0.005 0.5 1 0.005 1.0 
4080         
 200 33 0.165 2.5 2 0.010 0.5 1 0.005 0.5 30 0.150 3.0 
5100         
 200 19 0.095 5.5 6 0.030 2.5 13 0.065 4.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 87 8.700 100.0 2 0.200 20.0 5 0.500 20.0 80 8.000 8.0
Trend: 1.726 1.146 1.780  
Probability: 0.042 0.126 0.038