Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02066-0002-0000-8 |
Chemical Name: | Dimethyl sulfoxide |
CASRN: | 67-68-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 272561_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Dimethyl sulfoxide | 499 | 200 | 6 | 0.030 | 2.5 | 2 | 0.010 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
1500 | 200 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
4990 | 200 | 7 | 0.035 | 3.5 | 1 | 0.005 | 0.5 | 5 | 0.025 | 2.5 | 1 | 0.005 | 1.0 | ||
Positive Control: | Mitomycin-C | 0.75 | 200 | 73 | 0.365 | 26.5 | 30 | 0.150 | 12.5 | 43 | 0.215 | 15.5 | 0 | 0.000 | 0.0 |
Mitomycin-C | 5 | 50 | 98 | 1.960 | 62.0 | 12 | 0.240 | 22.0 | 26 | 0.520 | 38.0 | 60 | 1.200 | 6.0 | |
Trend: | 0.338 | 0.277 | -0.207 | ||||||||||||
Probability: | 0.368 | 0.391 | 0.582 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Medium | 0 | 200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 0.5 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 |
Test Chemical: | Dimethyl sulfoxide | 499 | 200 | 7 | 0.035 | 3.5 | 2 | 0.010 | 1.0 | 5 | 0.025 | 2.5 | 0 | 0.000 | 0.0 |
1500 | 200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
4990 | 200 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | 3 | 0.015 | 1.5 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 50 | 50 | 41 | 0.820 | 46.0 | 16 | 0.320 | 26.0 | 24 | 0.480 | 28.0 | 1 | 0.020 | 1.0 |
Trend: | -0.638 | -1.282 | -0.120 | ||||||||||||
Probability: | 0.738 | 0.900 | 0.548 |