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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0001-0000-8
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 822999_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1045 385 0.368 7.70 26.5 0.000
Test Chemical Dimethyl terephthalate 
1         
 50 1049 375 0.357 7.50 26.5 -2.969 
3         
 50 1046 372 0.356 7.44 26.5 -3.469 
10         
 50 1050 378 0.360 7.56 26.5 -2.286
Positive Control Mitomycin-C 
 0.0015    
 50 1045 565 0.541 11.30 26.5 46.753
Mitomycin-C 
 0.01      
 10 210 299 1.424 29.90 26.5 286.463
Trend: -0.322        
Probability: 0.626        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 385 0.367 7.70 26.0 0.000
Test Chemical Dimethyl terephthalate 
1         
 50 1048 368 0.351 7.36 26.0 -4.233 
3         
 50 1044 377 0.361 7.54 26.0 -1.515 
10         
 50 1050 383 0.365 7.66 26.0 -0.519
Positive Control Cyclophosphamide 
 0.5       
 50 1043 662 0.635 13.24 26.0 73.102
Cyclophosphamide 
2.5       
 10 210 365 1.738 36.50 26.0 374.026
Trend: 0.051        
Probability: 0.480