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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0010-0000-8
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 954536
Study Result: Negative


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Formamide 
 0         
 115 127 79 23 23
    106 100 84 26
    88 108 44 17
    113 65 92 27
Test Chemical Dimethyl terephthalate 
6.25      
 107 106 77 24 24
    111 112 97 29
    102 110 59 19
  
12.5       
 101 112 59 19 22
    102 133 61 20
    107 78 83 26
  
25         
 111 121 57 17 24
    109 82 116 36
    104 109 59 19
  
50         
 116 101 70 20 23
    112 142 74 22
    95 112 76 27
  
75         
 115 61 71 21 23
    98 107 90 31
    93 85 54 19
  
100         
 108 117 70 22 20
    116 118 57 16
    110 104 74 23
Positive Control Methyl Methane Sulfonate 
5         
 96 53 405 140 159*
    104 81 579 186
    96 76 432 150

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Formamide 
 0         
 103 93 76 25 26
    121r 141 110 30
    114 110 85 25
    108 97 87 27
Test Chemical Dimethyl terephthalate 
6.25      
 111 131 72 22 28
    107 118 108 34
    104 92 92 29
  
12.5       
 114 135 94 28 34
    104 90 126 40
    108 106 114 35
  
25         
 111 97 114 34 35
    109 45 110 34
    120 123 134 37
  
50         
 110 94 125 38 33
    107 68 97 30
    111 119 97 29
  
75         
 115 108 117 34 30
    104 89 88 28
    104 73 83 26
  
100         
 118 103 88 25 26
    107 114 101 31
    119 95 76 21
Positive Control Methyl Methane Sulfonate 
5         
 83 47 455 183 217*
    71 53 618 292
    87 74 462 177

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Formamide 
 0         
 109 141 161 49 50
    110 100 183 55
    97 76 125 43
    87 83 138 53
Test Chemical Dimethyl terephthalate 
6.25      
 111# 27 178 53 54
    104 84 150 48
    112 68 199 59
  
12.5       
 103 83 139 45 52
    86 77 150 58
    101 81 163 54
  
25         
 79 58 137 58 65
    62 73 137 74
    110# 92 210 64
  
50         
 111 33 143 43 51
    121r 81 194 54
    115 89 206 60
  
75         
 101 50 189 63 54
    110 58 199 60
    119 114 136 38
  
100         
 115 86 178 52 50
    106 39 127 40
    108 54 192 59
Positive Control 3-Methylcholanthrene 
2.5       
 52 9 811 518 467*
    72 13 797 368
    46# 9 714 516

Induced S9 Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Formamide 
 0         
 118 92 132 37 40
    102 65 138 45
    113 104 126 37
    117 140 145 41
Test Chemical Dimethyl terephthalate 
6.25      
 111 81 99 30 32
    114 85 113 33
    111 72 107 32
  
12.5       
 115 72 123 36 33
    116 87 92 26
    111 74 124 37
  
25         
 112 94 132 39 42
    104 61 135 43
    109 42 137 42
  
50         
 108 69 139 43 45
    112 88 124 37
    98 68 163 55
  
75         
 115 111 168 49 47
    93 72 160 58
    107 99 108 34
  
100         
 111 54 183 55 51
    95 45 164 57
    101 88 126 42
Positive Control 3-Methylcholanthrene 
2.5       
 48 9 537 374 318*
    81 51 787 326
    98 65 746 253

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination