Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02067-0010-0000-8
Chemical Name:	Dimethyl terephthalate
CASRN:	120-61-6
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	954536
Study Result:	Negative

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Formamide	0	115	127	79	23	23
			106	100	84	26
			88	108	44	17
			113	65	92	27
Test Chemical	Dimethyl terephthalate	6.25	107	106	77	24	24
			111	112	97	29
			102	110	59	19
		12.5	101	112	59	19	22
			102	133	61	20
			107	78	83	26
		25	111	121	57	17	24
			109	82	116	36
			104	109	59	19
		50	116	101	70	20	23
			112	142	74	22
			95	112	76	27
		75	115	61	71	21	23
			98	107	90	31
			93	85	54	19
		100	108	117	70	22	20
			116	118	57	16
			110	104	74	23
Positive Control	Methyl Methane Sulfonate	5	96	53	405	140	159*
			104	81	579	186
			96	76	432	150

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Formamide	0	103	93	76	25	26
			121r	141	110	30
			114	110	85	25
			108	97	87	27
Test Chemical	Dimethyl terephthalate	6.25	111	131	72	22	28
			107	118	108	34
			104	92	92	29
		12.5	114	135	94	28	34
			104	90	126	40
			108	106	114	35
		25	111	97	114	34	35
			109	45	110	34
			120	123	134	37
		50	110	94	125	38	33
			107	68	97	30
			111	119	97	29
		75	115	108	117	34	30
			104	89	88	28
			104	73	83	26
		100	118	103	88	25	26
			107	114	101	31
			119	95	76	21
Positive Control	Methyl Methane Sulfonate	5	83	47	455	183	217*
			71	53	618	292
			87	74	462	177

Induced S9 Trial: 1 Experiment Call: Negative and Non-Toxic
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Formamide	0	109	141	161	49	50
			110	100	183	55
			97	76	125	43
			87	83	138	53
Test Chemical	Dimethyl terephthalate	6.25	111#	27	178	53	54
			104	84	150	48
			112	68	199	59
		12.5	103	83	139	45	52
			86	77	150	58
			101	81	163	54
		25	79	58	137	58	65
			62	73	137	74
			110#	92	210	64
		50	111	33	143	43	51
			121r	81	194	54
			115	89	206	60
		75	101	50	189	63	54
			110	58	199	60
			119	114	136	38
		100	115	86	178	52	50
			106	39	127	40
			108	54	192	59
Positive Control	3-Methylcholanthrene	2.5	52	9	811	518	467*
			72	13	797	368
			46#	9	714	516

Induced S9 Trial: 2 Experiment Call: Negative and Non-Toxic
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Dimethyl Formamide	0	118	92	132	37	40
			102	65	138	45
			113	104	126	37
			117	140	145	41
Test Chemical	Dimethyl terephthalate	6.25	111	81	99	30	32
			114	85	113	33
			111	72	107	32
		12.5	115	72	123	36	33
			116	87	92	26
			111	74	124	37
		25	112	94	132	39	42
			104	61	135	43
			109	42	137	42
		50	108	69	139	43	45
			112	88	124	37
			98	68	163	55
		75	115	111	168	49	47
			93	72	160	58
			107	99	108	34
		100	111	54	183	55	51
			95	45	164	57
			101	88	126	42
Positive Control	3-Methylcholanthrene	2.5	48	9	537	374	318*
			81	51	787	326
			98	65	746	253

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination