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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0011-0000-9
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 454441_SCE
Study Result: Equivocal


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/11/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 4.79 ± 0.211
Test Chemical Dimethyl terephthalate 
500         
 4 4.98 ± 0.422
  
1000         
 4 5.15 ± 0.327
  
2000         
 4 4.92 ± 0.577


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 12/22/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 4 6.76 ± 0.739
Test Chemical Dimethyl terephthalate 
500         
 4 5.99 ± 0.453
  
1000         
 4 7.19 ± 0.477
  
2000         
 4 8.45 ± 0.733
Positive Control Dimethylbenzanthracene 
2.5       
 4 8.29 ± 0.433


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/21/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Corn Oil 
 0         
 5 5.06 ± 0.352
Test Chemical Dimethyl terephthalate 
1500         
 5 6.26 ± 0.307
  
2000         
 8 6.42 ± 0.735
Positive Control Dimethylbenzanthracene 
2.5       
 4 9.01 ± 0.782


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed