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Study Information
Study Attribute Value
CEBS Accession Number: 002-02067-0012-0000-0
Chemical Name: Dimethyl terephthalate
CASRN: 120-61-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 454441_CA
Study Result: Equivocal

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/31/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.5255
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 26.75 ± 2.56 0.0000
Test Chemical Dimethyl terephthalate 
500         
 8 0.50 ± 0.33 0.2815
  
1000         
 8 0.75 ± 0.37 0.1580
  
2000         
 8 0.25 ± 0.25 0.5000
Vehicle Control No Stressor 
 0         
 8 0.25 ± 0.25 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/17/87 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.4259
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 11.50 ± 1.50 0.0000
Test Chemical Dimethyl terephthalate 
500         
 8 3.50 ± 0.98 0.0035
  
1000         
 8 1.50 ± 0.63 0.1573
  
2000         
 8 1.75 ± 0.59 0.1015
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/08/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0470
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 13.50 ± 1.50 0.0000
Test Chemical Dimethyl terephthalate 
375         
 7 1.71 ± 0.81 0.1974
  
500         
 8 2.75 ± 0.92 0.0340
  
625         
 7 2.29 ± 0.92 0.0808
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed