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Study Information
Study Attribute Value
CEBS Accession Number: 002-02072-0001-0000-4
Chemical Name: Dimethylcarbamoyl chloride
CASRN: 79-44-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 751170_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/08/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 407 0.388 8.14 26.0 0.000
Test Chemical Dimethylcarbamoyl chloride 
 0.05      
 50 1050 442 0.421 8.84 26.0 8.600 
 0.5       
 50 1050 429 0.409 8.58 26.0 5.405 
5         
 50 1050 471 0.449 9.42 26.0 15.725 
50         
 50 1049 512 0.488 10.24 26.0 25.918 
500         
 11 239 325 1.360 29.55 26.0 250.817
Positive Control Triethylenemelamine 
 0.025     
 50 1048 2185 2.085 43.70 26.0 437.880
Trend: 11.404        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/08/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 430 0.410 8.60 26.0 0.000
Test Chemical Dimethylcarbamoyl chloride 
 0.05      
 50 1051 459 0.437 9.18 26.0 6.541 
 0.5       
 50 1048 439 0.419 8.78 26.0 2.190 
5         
 50 1050 469 0.447 9.38 26.0 8.966 
50         
 50 1050 560 0.533 11.20 26.0 30.109 
500         
 50 1051 2101 1.999 42.02 26.0 387.675
Positive Control Cyclophosphamide 
1.5       
 50 1051 2106 2.004 42.12 26.0 388.835
Trend: 38.063        
Probability: 0.000