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Study Information
Study Attribute Value
CEBS Accession Number: 002-02072-0003-0000-6
Chemical Name: Dimethylcarbamoyl chloride
CASRN: 79-44-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 754170_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 09/10/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 408 0.390 8.16 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 387 0.370 7.74 26.0 -5.147
Test Chemical Dimethylcarbamoyl chloride 
110         
 50 1047 447 0.427 8.94 26.0 9.559 
210         
 50 1050 524 0.499 10.48 26.0 28.064 
420         
 50 1047 858 0.819 17.16 26.0 110.294 
840         
 28 585 396 0.677 14.14 28.0 73.710 
1700         
 32 673 850 1.263 26.56 28.0 224.108 
3400         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Triethylenemelamine 
 0.015     
 50 1048 2848 2.718 56.96 26.0 597.373
Trend: 23.349        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/10/1980    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 364 0.348 7.28 26.5 -11.389
Dimethyl Sulfoxide 
0         
 50 1043 410 0.393 8.20 26.5 0.000
Test Chemical Dimethylcarbamoyl chloride 
260         
 50 1041 530 0.509 10.60 26.5 29.517 
530         
 50 1038 1020 0.983 20.40 26.5 149.979 
1100         
 50 1047 1666 1.591 33.32 26.5 304.789 
2100         
 50 1047 2293 2.190 45.86 26.5 457.132 
4200         
 5 100 273 2.730 54.60 26.5 594.485 
8400         
 0 0 0 0.000 0.00 26.5 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1048 1878 1.792 37.56 26.5 355.863
Trend: 46.570        
Probability: 0.000