Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02072-0004-0000-7 |
Chemical Name: | Dimethylcarbamoyl chloride |
CASRN: | 79-44-7 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 754170_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Positive |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
Dimethyl Sulfoxide | 0 | 100 | 4 | 0.040 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | |
Test Chemical: | Dimethylcarbamoyl chloride | 11 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 |
42 | 100 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | 5 | 0.050 | 5.0 | 0 | 0.000 | 0.0 | ||
170 | 100 | 9 | 0.090 | 8.0 | 1 | 0.010 | 1.0 | 7 | 0.070 | 6.0 | 1 | 0.010 | 1.0 | ||
670 | 100 | 7 | 0.070 | 7.0 | 1 | 0.010 | 1.0 | 6 | 0.060 | 6.0 | 0 | 0.000 | 0.0 | ||
2700 | 100 | 10 | 0.100 | 10.0 | 1 | 0.010 | 1.0 | 8 | 0.080 | 8.0 | 1 | 0.010 | 1.0 | ||
Positive Control: | Triethylenemelamine | 0.25 | 100 | 41 | 0.410 | 34.0 | 10 | 0.100 | 8.0 | 30 | 0.300 | 28.0 | 1 | 0.010 | 1.0 |
Trend: | 2.703 | 0.885 | 2.821 | ||||||||||||
Probability: | 0.003 | 0.188 | 0.002 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 |
Dimethyl Sulfoxide | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 2.0 | |
Test Chemical: | Dimethylcarbamoyl chloride | 530 | 100 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 1.0 | 1 | 0.010 | 1.0 |
1100 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
2100 | 100 | 8 | 0.080 | 6.0 | 1 | 0.010 | 1.0 | 6 | 0.060 | 5.0 | 1 | 0.010 | 1.0 | ||
4200 | 100 | 21 | 0.210 | 15.0 | 1 | 0.010 | 1.0 | 19 | 0.190 | 13.0 | 1 | 0.010 | 1.0 | ||
8400 | 47 | 15 | 0.319 | 23.0 | 1 | 0.021 | 2.0 | 14 | 0.298 | 21.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 25 | 100 | 42 | 0.420 | 32.0 | 21 | 0.210 | 18.0 | 18 | 0.180 | 14.0 | 3 | 0.030 | 3.0 |
Trend: | 5.337 | 1.850 | 5.755 | ||||||||||||
Probability: | 0.000 | 0.032 | 0.000 |