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Study Information
Study Attribute Value
CEBS Accession Number: 002-02084-0001-0000-7
Chemical Name: Dimethylvinyl chloride (DMVC)
CASRN: 513-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154330_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 07/19/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 389 0.373 7.78 27.0 0.000
Negative (Not Specified) 
0         
 50 1040 340 0.327 6.80 27.0 -12.344
Test Chemical Dimethylvinyl chloride (DMVC) 
25         
 50 1047 445 0.425 8.90 27.0 13.959 
50         
 50 1047 458 0.437 9.16 27.0 17.288 
160         
 50 1044 536 0.513 10.72 27.0 37.657 
300         
 50 1046 614 0.587 12.28 27.0 57.388 
400         
 50 1047 611 0.584 12.22 27.0 56.469
Positive Control Mitomycin-C 
 0.05      
 50 1039 1188 1.143 23.76 27.0 206.574
Mitomycin-C 
 0.1       
 50 1041 1583 1.521 31.66 27.0 307.723
Trend: 9.060        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/13/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1030 349 0.339 6.98 26.0 0.000
Negative (Not Specified) 
0         
 50 1040 314 0.302 6.28 26.0 -10.894
Test Chemical Dimethylvinyl chloride (DMVC) 
100         
 50 1044 480 0.460 9.60 26.0 35.691 
250         
 50 1043 570 0.547 11.40 26.0 61.288 
500         
 50 1042 710 0.681 14.20 26.0 101.096 
750         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.05      
 50 1032 1005 0.974 20.10 26.0 187.408
Trend: 11.197        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/14/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 375 0.362 7.50 27.0 0.000
Negative (Not Specified) 
0         
 50 1029 383 0.372 7.66 27.0 2.828
Test Chemical Dimethylvinyl chloride (DMVC) 
50         
 50 1037 355 0.342 7.10 27.0 -5.425 
160         
 50 1033 449 0.435 8.98 27.0 20.081 
500         
 50 1032 442 0.428 8.84 27.0 18.324 
1600         
 50 1022 687 0.672 13.74 27.0 85.710 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1035 1100 1.063 22.00 27.0 193.617
Trend: 10.703        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/13/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1043 420 0.403 8.40 26.0 -4.511
Dimethyl Sulfoxide 
0         
 50 1041 439 0.422 8.78 26.0 0.000
Test Chemical Dimethylvinyl chloride (DMVC) 
250         
 50 1048 407 0.388 8.14 26.0 -7.909 
500         
 50 1043 467 0.448 9.34 26.0 6.174 
750         
 50 1052 594 0.565 11.88 26.0 33.893 
1600         
 0 0 0 0.000 0.00 26.0 N/A 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
1.5       
 50 1048 1533 1.463 30.66 26.0 246.870
Cyclophosphamide 
2         
 50 1049 1868 1.781 37.36 26.0 322.267
Trend: 4.776        
Probability: 0.000