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Study Information
Study Attribute Value
CEBS Accession Number: 002-02084-0002-0000-8
Chemical Name: Dimethylvinyl chloride (DMVC)
CASRN: 513-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 154330_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 06/01/1983    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dimethylvinyl chloride (DMVC)
16         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
50         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
160         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 3 0.030 3.0 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0
1600         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.5       
100 46 0.460 33.0 27 0.270 21.0 19 0.190 18.0 0 0.000 0.0
Trend: 1.156 0.817 0.813  
Probability: 0.124 0.207 0.208  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/01/1983    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 3 0.030 3.0 1 0.010 1.0 2 0.020 2.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dimethylvinyl chloride (DMVC)
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
160         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
1600         
100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
5000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
100 34 0.340 25.0 24 0.240 20.0 10 0.100 10.0 0 0.000 0.0
Trend: 1.501 0.703 1.417  
Probability: 0.067 0.241 0.078  


Trial #:2   Activation: No Activation    Date: 07/17/1983    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dimethylvinyl chloride (DMVC)
50         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
100         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
250         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
750         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C
 0.25      
100 21 0.210 20.0 15 0.150 15.0 6 0.060 6.0 0 0.000 0.0
Trend: 0.693 -1.028 2.005  
Probability: 0.244 0.848 0.022  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/17/1983    Harvest Time: 12 hour(s)   Trial Call: Negative   
  Dose
µg/mL
Total
Cells Examined
Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
No. of
Abs.
Abs
Per
Cell
% Cells
With
Abs
Vehicle Control: Negative (Not Specified)
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide
0         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: Dimethylvinyl chloride (DMVC)
250         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
500         
100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
1600         
100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
3000         
0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide
50         
100 49 0.490 34.0 27 0.270 20.0 22 0.220 19.0 0 0.000 0.0
Trend: 1.451 1.451 0.000  
Probability: 0.073 0.073 0.000