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Study Information
Study Attribute Value
CEBS Accession Number: 002-02084-0015-0000-2
Chemical Name: Dimethylvinyl chloride (DMVC)
CASRN: 513-37-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 452004
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 114 111 86 25 81
    118 126 94 26
    81 48 597 245
    112 116 85 25
Test Chemical Dimethylvinyl chloride (DMVC) 
 0.1       
 105 70 116 37 34
    74 83 78 35
    100 83 88 29
  
 0.2       
 96 68 108 37 35
    97 70 118 40
    91 79 77 28
  
 0.3       
 96 69 84 29 38
    95 32 106 37
    82 52 117 48
Positive Control Methyl Methane Sulfonate 
5         
 75 73 520 230 254*
    67 42 499 249
    58 33 490 283

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
uL/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Ethanol 
 0         
 102# 98 69 23 20
    94 120 70 25
    116 101 56 16
    91 81 43 16
Test Chemical Dimethylvinyl chloride (DMVC) 
 0.1       
 92 74 68 25 21
    85 80 41 16
    85 69 55 22
  
 0.2       
 67 38 48 24 28
    86 64 64 25
    71 62 76 36
  
 0.4       
 109 11 185 57 66*
    78 33 192 82
    76 29 131 58
  
 0.6       
 80 10 417 174 178*
    107 14 373 117
    55# 8 396 242
  
 0.8       
   
   
Positive Control Methyl Methane Sulfonate 
5         
 90# 66 450 167 182*
    80 75 480 201
    83 61 437 176

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination