| Study Attribute | Value | 
|---|---|
| CEBS Accession Number: | 002-02084-0015-0000-2 | 
| Chemical Name: | Dimethylvinyl chloride (DMVC) | 
| CASRN: | 513-37-1 | 
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity | 
| NTP Study ID: | 452004 | 
| Study Result: | Positive | 
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
| Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Ethanol | 0 | 114 | 111 | 86 | 25 | 81 | 
| 118 | 126 | 94 | 26 | ||||
| 81 | 48 | 597 | 245 | ||||
| 112 | 116 | 85 | 25 | ||||
| Test Chemical | Dimethylvinyl chloride (DMVC) | 0.1 | 105 | 70 | 116 | 37 | 34 | 
| 74 | 83 | 78 | 35 | ||||
| 100 | 83 | 88 | 29 | ||||
| 0.2 | 96 | 68 | 108 | 37 | 35 | ||
| 97 | 70 | 118 | 40 | ||||
| 91 | 79 | 77 | 28 | ||||
| 0.3 | 96 | 69 | 84 | 29 | 38 | ||
| 95 | 32 | 106 | 37 | ||||
| 82 | 52 | 117 | 48 | ||||
| Positive Control | Methyl Methane Sulfonate | 5 | 75 | 73 | 520 | 230 | 254* | 
| 67 | 42 | 499 | 249 | ||||
| 58 | 33 | 490 | 283 | ||||
| Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Ethanol | 0 | 102# | 98 | 69 | 23 | 20 | 
| 94 | 120 | 70 | 25 | ||||
| 116 | 101 | 56 | 16 | ||||
| 91 | 81 | 43 | 16 | ||||
| Test Chemical | Dimethylvinyl chloride (DMVC) | 0.1 | 92 | 74 | 68 | 25 | 21 | 
| 85 | 80 | 41 | 16 | ||||
| 85 | 69 | 55 | 22 | ||||
| 0.2 | 67 | 38 | 48 | 24 | 28 | ||
| 86 | 64 | 64 | 25 | ||||
| 71 | 62 | 76 | 36 | ||||
| 0.4 | 109 | 11 | 185 | 57 | 66* | ||
| 78 | 33 | 192 | 82 | ||||
| 76 | 29 | 131 | 58 | ||||
| 0.6 | 80 | 10 | 417 | 174 | 178* | ||
| 107 | 14 | 373 | 117 | ||||
| 55# | 8 | 396 | 242 | ||||
| 0.8 | |||||||
| Positive Control | Methyl Methane Sulfonate | 5 | 90# | 66 | 450 | 167 | 182* | 
| 80 | 75 | 480 | 201 | ||||
| 83 | 61 | 437 | 176 | ||||
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination
 
                        