Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02084-0015-0000-2 |
Chemical Name: | Dimethylvinyl chloride (DMVC) |
CASRN: | 513-37-1 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
NTP Study ID: | 452004 |
Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 114 | 111 | 86 | 25 | 81 |
118 | 126 | 94 | 26 | ||||
81 | 48 | 597 | 245 | ||||
112 | 116 | 85 | 25 | ||||
Test Chemical | Dimethylvinyl chloride (DMVC) | 0.1 | 105 | 70 | 116 | 37 | 34 |
74 | 83 | 78 | 35 | ||||
100 | 83 | 88 | 29 | ||||
0.2 | 96 | 68 | 108 | 37 | 35 | ||
97 | 70 | 118 | 40 | ||||
91 | 79 | 77 | 28 | ||||
0.3 | 96 | 69 | 84 | 29 | 38 | ||
95 | 32 | 106 | 37 | ||||
82 | 52 | 117 | 48 | ||||
Positive Control | Methyl Methane Sulfonate | 5 | 75 | 73 | 520 | 230 | 254* |
67 | 42 | 499 | 249 | ||||
58 | 33 | 490 | 283 |
Conc. uL/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
---|---|---|---|---|---|---|---|
Vehicle Control | Ethanol | 0 | 102# | 98 | 69 | 23 | 20 |
94 | 120 | 70 | 25 | ||||
116 | 101 | 56 | 16 | ||||
91 | 81 | 43 | 16 | ||||
Test Chemical | Dimethylvinyl chloride (DMVC) | 0.1 | 92 | 74 | 68 | 25 | 21 |
85 | 80 | 41 | 16 | ||||
85 | 69 | 55 | 22 | ||||
0.2 | 67 | 38 | 48 | 24 | 28 | ||
86 | 64 | 64 | 25 | ||||
71 | 62 | 76 | 36 | ||||
0.4 | 109 | 11 | 185 | 57 | 66* | ||
78 | 33 | 192 | 82 | ||||
76 | 29 | 131 | 58 | ||||
0.6 | 80 | 10 | 417 | 174 | 178* | ||
107 | 14 | 373 | 117 | ||||
55# | 8 | 396 | 242 | ||||
0.8 | |||||||
Positive Control | Methyl Methane Sulfonate | 5 | 90# | 66 | 450 | 167 | 182* |
80 | 75 | 480 | 201 | ||||
83 | 61 | 437 | 176 |
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination