Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-02084-0015-0000-2
Chemical Name:	Dimethylvinyl chloride (DMVC)
CASRN:	513-37-1
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	452004
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	114	111	86	25	81
			118	126	94	26
			81	48	597	245
			112	116	85	25
Test Chemical	Dimethylvinyl chloride (DMVC)	0.1	105	70	116	37	34
			74	83	78	35
			100	83	88	29
		0.2	96	68	108	37	35
			97	70	118	40
			91	79	77	28
		0.3	96	69	84	29	38
			95	32	106	37
			82	52	117	48
Positive Control	Methyl Methane Sulfonate	5	75	73	520	230	254*
			67	42	499	249
			58	33	490	283

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. uL/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Ethanol	0	102#	98	69	23	20
			94	120	70	25
			116	101	56	16
			91	81	43	16
Test Chemical	Dimethylvinyl chloride (DMVC)	0.1	92	74	68	25	21
			85	80	41	16
			85	69	55	22
		0.2	67	38	48	24	28
			86	64	64	25
			71	62	76	36
		0.4	109	11	185	57	66*
			78	33	192	82
			76	29	131	58
		0.6	80	10	417	174	178*
			107	14	373	117
			55#	8	396	242
		0.8


Positive Control	Methyl Methane Sulfonate	5	90#	66	450	167	182*
			80	75	480	201
			83	61	437	176

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination