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Study Information
Study Attribute Value
CEBS Accession Number: 002-02087-0001-0000-0
Chemical Name: Dioxathion
CASRN: 78-34-2
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 472509_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 08/03/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 413 0.400 8.26 26.1 0.000
Test Chemical Dioxathion 
12.5       
 50 1025 490 0.478 9.80 32.6 19.454 
41.7       
 50 1036 515 0.497 10.30 32.6 24.216 
125.2       
 50 1011 556 0.550 11.12 32.6 37.421 
417.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1037 569 0.549 11.38 26.1 37.108
Mitomycin-C 
 0.01      
 5 103 198 1.922 39.60 26.1 380.350
Trend: 4.825        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/11/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 438 0.421 8.76 25.5 0.000
Test Chemical Dioxathion 
198.6       
 50 1020 514 0.504 10.28 34.2 19.653 
247.4       
 50 1033 562 0.544 11.24 34.2 29.180 
296.4       
 50 1033 549 0.531 10.98 34.2 26.192 
348.5       
 0 0 0 0.000 0.00 34.2 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1041 657 0.631 13.14 25.5 49.856
Mitomycin-C 
 0.01      
 5 103 204 1.981 40.80 25.5 370.275
Trend: 3.801        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/03/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 434 0.421 8.68 26.1 0.000
Test Chemical Dioxathion 
12.5       
 50 1025 440 0.429 8.80 26.1 1.976 
41.7       
 50 1036 560 0.541 11.20 32.6 28.410 
125.2       
 50 1024 542 0.529 10.84 32.6 25.738 
417.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1042 716 0.687 14.32 26.1 63.235
Cyclophosphamide 
2         
 5 102 315 3.088 63.00 26.1 633.634
Trend: 4.552        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 08/11/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1034 486 0.470 9.72 25.5 0.000
Test Chemical Dioxathion 
247.4       
 50 1038 704 0.678 14.08 34.2 44.298 
296.4       
 50 1022 688 0.673 13.76 34.2 43.226 
348.5       
 50 1038 748 0.721 14.96 34.2 53.316 
400.6       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1038 654 0.630 13.08 25.5 34.049
Cyclophosphamide 
2         
 5 101 178 1.762 35.60 25.5 274.958
Trend: 6.672        
Probability: 0.000