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Study Information
Study Attribute Value
CEBS Accession Number: 002-02088-0001-0000-1
Chemical Name: Diphenhydramine hydrochloride
CASRN: 147-24-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 195192_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 07/10/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1043 368 0.353 7.36 27.0 0.000
Test Chemical Diphenhydramine hydrochloride
5         
50 1034 398 0.385 7.96 27.0 9.094
15         
50 1040 396 0.381 7.92 27.0 7.919
50         
50 1039 372 0.358 7.44 27.0 1.476
Positive Control Mitomycin-C
 0.002     
50 1037 583 0.562 11.66 27.0 59.341
Mitomycin-C
 0.01      
10 210 343 1.633 34.30 27.0 362.926
Trend: 0.127        
Probability: 0.449        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/10/1984    Trial Call: Negative   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified)
0         
50 1045 460 0.440 9.20 25.5 0.000
Test Chemical Diphenhydramine hydrochloride
15         
50 1047 433 0.414 8.66 25.5 -6.049
50         
50 1046 415 0.397 8.30 25.5 -9.869
150         
50 1043 436 0.418 8.72 25.5 -5.036
Positive Control Cyclophosphamide
 0.5       
50 1041 749 0.720 14.98 25.5 63.452
Cyclophosphamide
2.5       
10 211 396 1.877 39.60 25.5 326.355
Trend: -0.949        
Probability: 0.829